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Retired NBME 25 Answers

nbme25/Block 1/Question#28 (reveal difficulty score)
A 28-year-old woman comes to the physician ...
Membranous 🔍 / 📺 / 🌳 / 📖
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submitted by shak360(20)
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If the renal condition has “proliferative” in the name, it has subendothelial deposits. If it doesn’t have “proliferative” in the name, it must not be subendothelial. So for instance, membranoproliferative glomerulonephritis (MPGN) and diffuse proliferative glomerulonephritis (DPGN); what would you see on biopsy? -> USMLE answer = subendothelial deposits. (from Mehlman Medical Renal)

In this question, this person has irregular subepithelial electron-dense deposits so the correct answer CAN NOT contain the word proliferative. Furthermore, she has 3+ protein in the urine but no evidence of blood indicating that it must be membranous nephropathy.

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shak360  Another thing to note is that the "diffuse thickening of the glomerular capillary wall" is equivalent to "membranous" in disease nomenclature. +



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