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Retired NBME 25 Answers

nbme25/Block 1/Question#42 (reveal difficulty score)
An 18-ear-old man with ALL comes to the ...
Amphotericin B ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—shak360(19)
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Cryptococcus neoformans is common in patients with immunocompromising conditions. Usually, I have this infectious yeast associated with India Ink staining (wherein it presents with a clear halo) but on mucicarmine stain, it presents with a red inner capsule, and the narrow budding can be more easily appreciated.

It causes cryptococcosis, meningitis, and encephalitis ("soap bubble" lesions in the brain).

The treatment is amphotericin B with flucytosine, followed by fluconazole for cryptococcal meningitis.

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