need help with your account or subscription? click here to email us (or see the contact page)
join telegramNEW! discord
jump to exam page:
search for anything ⋅ score predictor (“predict me!”)

Retired NBME 25 Answers

nbme25/Block 2/Question#39 (reveal difficulty score)
A 28-year-old woman, gravida 4, para 0, ...
Antiphospholipid antibodies 🔍 / 📺 / 🌳 / 📖
tags:

 Login (or register) to see more


 +0  upvote downvote
submitted by shak360(23)
The site was recently locked🔒
It can be re-accessed by making a purchase.

Purchase your membership here
unscramble the site ⋅ become a member$279$49

iAitnopopsphhdli ednsormy si dasoidgne sedab no rcrteenur ouvens ortbhssemo o,(ilbgaa)yptyhrelcui tfeqrune raisrag,cemis ryeimhnobct,paoto nad a teiesialp-vsof dpiar apmals eangri test. tI is eidaoscsta itwh nclliica reirtica nnucidgli a shtoryi fo otobhrsmsi ar(eialtr or nve)suo or eoantnsupso ioabrtno glano hwti oaarbotylr singdfin fo psulu citntanlgaoa,u ain,ciinporalidt ai-2nβt tongeiyoclpr I aosntid.ibe

unscramble the site ⋅ become a member$279$49

It is also associated with an increased PTT. PTT is prolonged because the autoantibodies bind to the phospholipid reagent used in the PTT test, inactivating it and falsely prolonging the PTT. This permanent binding and PTT prolongation are not corrected by mixing 1:1 with fresh-frozen plasma. Correction of an elevated PTT would be seen in clotting factor deficiencies. APS is more directly diagnosed by detecting specific serum autoantibodies (eg, anticardiolipin or anti–beta-2-glycoprotein).

The false-positive rapid plasma reagin test result occurs because the reagent used in the test contains cardiolipin, which reacts with the patient’s autoantibodies.

The deep vein thrombosis and findings of SLE suggest a concurrent acquired antiphospholipid syndrome (APS), which causes hypercoagulability. This may lead to arterial and venous thrombi, thrombocytopenia, livedo reticularis, stroke, and pulmonary embolism. The syndrome is also associated with recurrent miscarriage and false-positive syphilis tests. APS can be primary or secondary to lupus or other autoimmune disorders. The low platelets can be due to the APS or due to SLE.

+/- shak360(23)


Must-See Comments from nbme25


search for anything NEW!