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NBME 25 Answers

nbme25/Block 3/Question#10 (reveal difficulty score)
A 7-year-old girl is admitted to the hospital ...
Mutation in the enzyme that increases K_m ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ
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submitted by โˆ—shak360(14)

The patient's enzyme needs more substrate to achieve the same effect as the normal enzyme.

The Km is the substrate concentration at which the enzyme achieves 50% maximal concentration.

More substrate is needed in the patient to reach the 50% maximal velocity than is needed in the normal patient so it must be that there is a mutation in the enzyme that increases Km.




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