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NBME 27 Answers

nbme27/Block 1/Question#17 (reveal difficulty score)
A 51-year-old woman comes to the physician ...
(histology pointing to a Parietal cell) ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–

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submitted by โˆ—shak360(14)

Many objects on histology have a distinctive "fried egg" appearance, or cells that have a somewhat clear cytoplasm with central dark nuclei with distinct borders:

  • Mycoplasma pneumonia colonies on Eaton agar
  • Oligodendroglioma cells
  • Seminoma and Dysgerminoma cells (large cells with clear cytoplasm, distinct borders)
  • Parietal cells of the stomach due to their large size, central and round nucleus, and intensely acidophilic cytoplasm (in the middle region of the gastric gland)
  • Plasma cells in Multiple Myeloma (more commonly associated with clock face or cartwheel chromatin pattern in the nucleus)
  • Malassezia furfur (Tinea versicolor) (more commonly associated with a "spaghetti and meatballs" or :flying spaghetti monster" appearance on microscopy)
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