I thought the following fact was interesting and helps me remember which ones are pro - and anti-apoptotic (BCL-2 and BCL-X).
Anti-apoptotic:
Constitutive activation of BCL-2 by genetic aberrations is seen in tumors; in fact, BCL-2 stands for B cell lymphoma-2, so named for the tumor in which it was discovered as an oncogene.
Overexpression of BCL2 is a well-characterized mechanism that protects tumor cells from apoptosis. Approximately 85% of follicular lymphomas carry a chromosomal translocation that drives the overexpression of BCL2, and many other cancers are associated with high levels of expression of BCL2 or other antiapoptotic members of the BCL2 family.
Tumors survive because of their anti-apoptotic ability and BCL-2 and BCL-X are the proteins that are expressed in B-cell lymphomas.
Pro-apoptotic:
The release of cytochrome c by mitochondrial permeabilization promotes apoptosis via the proapoptotic proteins BAX and BAK, which are held in check by antiapoptotic members of the family (e.g., BCL2).
submitted by โshak360(19)
I thought the following fact was interesting and helps me remember which ones are pro - and anti-apoptotic (BCL-2 and BCL-X).
Anti-apoptotic:Constitutive activation of BCL-2 by genetic aberrations is seen in tumors; in fact, BCL-2 stands for B cell lymphoma-2, so named for the tumor in which it was discovered as an oncogene.
Overexpression of BCL2 is a well-characterized mechanism that protects tumor cells from apoptosis. Approximately 85% of follicular lymphomas carry a chromosomal translocation that drives the overexpression of BCL2, and many other cancers are associated with high levels of expression of BCL2 or other antiapoptotic members of the BCL2 family.
Tumors survive because of their anti-apoptotic ability and BCL-2 and BCL-X are the proteins that are expressed in B-cell lymphomas.
Pro-apoptotic:The release of cytochrome c by mitochondrial permeabilization promotes apoptosis via the proapoptotic proteins BAX and BAK, which are held in check by antiapoptotic members of the family (e.g., BCL2).