Loop diuretics act on the thick ascending limb of loop Henle
Thiazide diuretics act on the early distal convoluted tubule and inhibit NaCl reabsorption and reduce the diluting capacity of the nephron (also reduces the excretion of calcium)
Potassium-sparing diuretics act on the cortical collecting tubule (spironolactone and eplerenone are competitive aldosterone receptor antagonists while triamterene and amiloride block sodium channels in the cortical collecting duct)
submitted by โshak360(23)
Loop diuretics act on the thick ascending limb of loop Henle
Thiazide diuretics act on the early distal convoluted tubule and inhibit NaCl reabsorption and reduce the diluting capacity of the nephron (also reduces the excretion of calcium)
Potassium-sparing diuretics act on the cortical collecting tubule (spironolactone and eplerenone are competitive aldosterone receptor antagonists while triamterene and amiloride block sodium channels in the cortical collecting duct)