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Retired NBME 27 Answers

nbme27/Block 4/Question#3 (reveal difficulty score)
Development of the metanephros begins with ...
Reciprocal inductive ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—shak360(20)
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I can't find this in First Aid 2020 :(

Autoinductive signaling specifies a process in which cells or tissue are able to induce their own growth and differentiation in the absence of interaction with other cells (not the case in the development of the kidney).

Dorsalizing-ventralizing signaling refers to the development of the dorsal-ventral axis in embryology as determined by the neural tube. Signaling via release of factors such as bone morphogenetic protein, Wnt protein, transforming growth factor-รŸ, and fibroblast growth factor helps determine the dorsal-ventral axis.

Reciprocal inductive signaling describes the development of tissues on the basis of reciprocal signaling between two different cell types or tissues. The ureteric bud reacts to signaling from the metanephrogenic mesenchyme and leads to branching, with the subsequent development of the collecting ducts, while the mesenchyme reacts to signals from the uretic bud to cause the development of the renal tubules. When these two tissues (the ureteric bud and the metanephrogenic mesenchyme) are separated in culture, they are incapable of developing completely IN THE ABSENCE OF THE OTHER.

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