Alcohol leads to the induction of P450 enzymes that convert acetaminophen to N-acetyl-p-benzoquinoneimine (NAPQI), a toxic metabolite that causes hepatotoxicity in the setting of acetaminophen overdose.
M. Acidosis or decreased NAD+ and increased NADH do not play a direct role in acetaminophen-mediated hepatotoxicity!
submitted by โnamesthegame22(14)
Alcohol leads to the induction of P450 enzymes that convert acetaminophen to N-acetyl-p-benzoquinoneimine (NAPQI), a toxic metabolite that causes hepatotoxicity in the setting of acetaminophen overdose.
M. Acidosis or decreased NAD+ and increased NADH do not play a direct role in acetaminophen-mediated hepatotoxicity!