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Welcome to anu’s page.
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 +1  (free120#22)
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ywh is iotnpo D ) eethr si na ensiaecrd loikidlohe fo satailtliytcs ctiigfainns s.iidnnfg.. onwgr ?

micray  There is a decreased likelihood of statistically significant findings due to the much higher threshold (lower p-value). +3
drpee  The lower you make your p-value, the harder it will be to prove the relationship. That's why I always go with a p-value of .49 in my research. +1
lba9587  Because BOTH values are significant. PValue of Less than or equal to 0.05 is significant. +

 +3  (free120#11)
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atwh batou eht aecnsrei ni mplnayoru sacrlauv seernacsit ? tesnod PWPC lalf ni hgrmhcoaier kosch

ibestalkinyo  I think this may have something to do with hypoxic vasoconstriction? +
medguru2295  PCWP falls because there is less blood going into the Lungs and therefore, less blood coming out (decreased preload). However RESISTANCE is a measure of how difficult it is for blood to flow. That essentially means constriction. As stated above, it is likely hypoxic vasoconstriction as well as just global sympathetic attempt to maintain BP. If it said pressure in pulmonary arteries, it would likely be decreased as the vasoconstriction cannot full compensate the blood loss! +1
medguru2295  PCWP falls because there is less blood going into the Lungs and therefore, less blood coming out (decreased preload). However RESISTANCE is a measure of how difficult it is for blood to flow. That essentially means constriction. As stated above, it is likely hypoxic vasoconstriction as well as just global sympathetic attempt to maintain BP. If it said pressure in pulmonary arteries, it would likely be decreased as the vasoconstriction cannot full compensate the blood loss! +
sharpscontainer  Actually I don't think this is due to hypoxic vasoconstriction. The alveolar oxygen content of the lungs remains high, so there's still a good amount of oxygen getting into the pulmonary vessels, even if less of it can bind to Hb. I think instead it's that there's tons of sympathetic stimulation from hypovolemia, so alpha 1 in the pulmonary blood vessels is activated (which is separate from beta 2 bronchodilation which is a smooth muscle thing). https://www.ncbi.nlm.nih.gov/pubmed/10378571 +6
avocadotoast  PVR = (PAP - PCWP) / CO. There is a decrease in cardiac output in hypovolemic shock. Given its inverse relationship with pulmonary vascular resistance, we should choose an increase in PVR for this question. +1




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