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ergogenic22
there is a delayed onset hemolytic transfusion reaction which should be evaluated with direct cooms test.
https://www.ncbi.nlm.nih.gov/books/NBK448158/
+7
baja_blast
Dang, I didn't know that was the same thing as a direct Coombs test. I guess it makes sense in hindsight. Thanks!
+
sars
Theres a UWORLD question with a table displaying the different types of hemolytic reactions. Don't know the question ID. Agree with delayed hemolytic transfusion reaction due to formation of antibodies against donor non ABO antigens. Typically presents as an asymptomatic patient or mild symptoms (jaundice, anemia). Different from an acute hemolytic transfusion reaction, which is against ABO antigens.
+3
lukin4answer
Delayed Hemolytic transfusion reaction is Host IgG against donor's RBC Rh or minor blood group Ag.(details on UW 17780), we do direct COOMB test where we add "ANTI-immunoGLOBULIN Ab" to patient's blood, if RBC is coated with IgG, then they agglutinates. As we add "ANTI-immunoGLOBULIN", hence this direct coomb test is called = DIRECT ANTIGLOBULIN test (DAT).
I got it wrong too, then dug through.
UW Q 317, 891, 1851 mentions COOMB TEST= Direct ANTIGLOBULIN TEST :/ :/ :/
& it's usually the INDIRECT BILLIRUBIN that rises with hemolysis, not direct (option C)
+2
Direct Antiglobulin = Direct Coombs Test
Detects antibodies bound directly to RBCs. Hemolysis most likely due to something in the transfused blood (not sure why it took 4 weeks when Type 2 HS is supposed to be quicker but w/e).