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Retired NBME 13 Answers

nbme13/Block 4/Question#7 (reveal difficulty score)
A mouse melanoma, B-16, is highly metastatic. ...
Homing 🔍 / 📺 / 🌳 / 📖
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submitted by mario(1)
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this cells should be stem cell transplant, so homing is the environment that accept them and nourish them with growth factors to mature

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submitted by imkingran(1)
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This homing phenomenon may be related to tumour cell recognition of specific “exit sites” from the circulation or to awareness of a particularly favourable—or forbidding—“soil” of another tissue. This may occur because of an affinity that exists between receptor proteins on the surface of cancer cells and molecules that are abundant in specific tissues.


FA 2020, pg 221, "Hallmarks of Cancer"

Metastasis is defined by distant spread via blood/lymphatics --> binding to endothelium --> extravasation & homing.

Since metastasis to only one organ has been affected, it's safe to say this liver cell surface antibody has affected "homing" towards the liver.

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submitted by trazobone(97)
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This cells should be stem cell transplant so homing is the environment that accept them and nourish them with growth factors to mature

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trazobone  I don’t understand what I unscrambled. This does not apply to the question stem? +
trazobone  Apparently there is something called “hepatic homing” that occurs with mononuclear inflammatory cells I have never heard such a thing +2



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