NBME 13 Increased protein degradation (NBME Answers)

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Retired NBME 13 Answers

nbme13/Block 3/Question#14 (reveal difficulty score)
A previously healthy 40-year-old man is ...
Increased protein degradation 🔍 / 📺 / 🌳 / 📖
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submitted by ∗l0ud_minority(15)

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I got this wrong I thought Decreased Myosin Light Chain Phosphatase activity would play a factor from the long leg cast immobilization for 6 months. Not being able to use the leg would cause atrophy. But I was wrong.

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scoresloth same here +1

bugdrivergirl I thought that was only for smooth muscle though +

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submitted by ∗imgdoc(183)

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Specifically this process is called disuse atrophy. It is a type of atrophy, a cellular adaptation occurring in response to stress. This cellular adaptation causes protein degradation via ubiquitin proteasome pathway. This is why his calf is smaller than his other normal one.

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submitted by ∗imkingran(1)

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FA 2020 pg 206 - Cellular Adaptations - Atrophy

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imkingran https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775123/ +

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