Can also acquire the disorder from ingestion of glycyrrhetinic acid (present in licorice), which blocks the activity of 11ร-HSD. Glycrrhetinic acid, or enoxolone, is the active ingredient in licorice and primarily inhibits 11ร-HSD, which is responsible for the conversion of cortisol to cortisone. With increased concentrations of cortisol (and decreased concentrations of cortisone), downstream mineralocorticoid effects are observed, which cause inhibition of the RAAS pathway and decreased serum concentrations of its associated hormones.
submitted by โshak360(19)
Syndrome of Apparent Mineralocorticoid Excess
Autosomal recessive disorder
Can also acquire the disorder from ingestion of glycyrrhetinic acid (present in licorice), which blocks the activity of 11ร-HSD. Glycrrhetinic acid, or enoxolone, is the active ingredient in licorice and primarily inhibits 11ร-HSD, which is responsible for the conversion of cortisol to cortisone. With increased concentrations of cortisol (and decreased concentrations of cortisone), downstream mineralocorticoid effects are observed, which cause inhibition of the RAAS pathway and decreased serum concentrations of its associated hormones.
Mineralocorticoid receptor activity causes metabolic alkalosis, hypokalemia, hypertension, and decreased serum aldosterone.