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Retired NBME 29 Answers

nbme29/Block 1/Question#23 (reveal difficulty score)
The cartilage surrounding the knee supports ...
It has many surface negative charges ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: msk

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submitted by โˆ—namesthegame22(13)
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Chondroitin sulfate: is a highly polar molecule with many negative charges. Because of its polar nature, it has a strong affinity with water. In solution, it is heavily hydrated, which increases the overall volume of the complex, in contrast to its close-packed form when it is a dehydrated solid.

vs.

"It adheres to positively charged molecules of collagen in the extracellular matrix" (Choice A) may be a factual statement, but it does not explain the reorientation of chondroitin sulfate molecules when hydrated vs. dehydrated!!

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