Somatostatin analogs, such as octreotide, inhibit the release of VIP and counteract its effects.

Used to treat VIPoma: VIP is released by parasympathetic ganglia and leads to the increased secretion of water and electrolytes by the intestines as we as the increased relaxation of smooth muscle fibers in the gastrointestinal tract. Excess production results in profound fluid and electrolyte secretion into the gastrointestinal tract, severe watery diarrhea, electrolyte disturbances, achlorhydria, alkalosis, flushing, and vasodilation.

Also used to treat diarrhea