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NBME 29 Answers

nbme29/Block 2/Question#1 (reveal difficulty score)
Which of the following hormones decreases ...
Cortisol ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: pharm endo

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submitted by โˆ—namesthegame22(11)

Cortisol and glucocorticoids have a significant anti-inflammatory effect that is primarily mediated by decreasing production of prostaglandins and leukotrienes, which are derived from arachidonic acid.

Activation of the glucocorticoid receptor increases the production of annexin A1: which inhibits phospholipase A2; the enzyme responsible for producing arachidonic acid from phospholipids in membrane.

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