Cortisol and glucocorticoids have a significant anti-inflammatory effect that is primarily mediated by decreasing production of prostaglandins and leukotrienes, which are derived from arachidonic acid.
Activation of the glucocorticoid receptor increases the production of annexin A1: which inhibits phospholipase A2; the enzyme responsible for producing arachidonic acid from phospholipids in membrane.
submitted by โnamesthegame22(13)
Cortisol and glucocorticoids have a significant anti-inflammatory effect that is primarily mediated by decreasing production of prostaglandins and leukotrienes, which are derived from arachidonic acid.
Activation of the glucocorticoid receptor increases the production of annexin A1: which inhibits phospholipase A2; the enzyme responsible for producing arachidonic acid from phospholipids in membrane.