• Patient engaging in intense physical activity presenting with signs of heat stroke (fever, seizure/encephalopathy, dry hot skin) and rhabdomyolysis (myoglobinuria), who should be treated with IV fluids to decrease the risk of myoglobin pigment stones precipitating kidney damage
• Key idea: The major tenant of rhabdomyolysis management is aggressive IV fluid resuscitation because patients develop decreased effective circulating volume (due to fluid shifts into damaged muscle) and because patients are at risk for acute tubular necrosis secondary to myoglobinuria (with increased fluids helping to dilute these pigments and decrease the risk of tubular obstruction)

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