Welcome to catscan1979โs page.
Contributor score: 4
Comments ...
Subcomments ...
linwanrun1357
If we assume that they are not carriers (in the recessive case)
Then how came it can be AR๏ผ๏ผ๏ผ
+3
catscan1979
^exactly what's said above here. I think x-linked recessive is the least likely, but not impossible.
+4
furkan7
How is x linked recessive is the least likely when we need 2 carrier females for compatibility of both autosomal recessive and X linked recessive inheritence to this pedigree? I think probability of these two are the same. Am I missing something?
+1
My understanding is that if parents are unrelated by blood to those affected, we assume that they are not carriers (in the recessive case). Therefore, if we have a male father affected with x-linked recessive married to a non-carrier, there's no way any of his offspring would be affected.
"If one parent is not a carrier, then a child can only inherit a disease allele from the other parent. In these problems, we can assume that any individual marrying into the family is not a carrier." https://www.cs.cmu.edu/~genetics/units/instructions/instructions-CP.pdf