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submitted by cassdawg(1781), visit this page
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Giant granules in neutrophils and eosinophils combined with immunodeficiency (recurrent infections) and partial albinism is characteristic for Chediak-Higashi which is caused by defect in the lysosomal trafficking regulator gene [FA2020 p116]

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fanderina  but why is the rough ER dilated? +1
kaymin1234  Due to a trafficking defect, the proteins in the rER can't go to the golgi, so increased protein in the rER will dilate it. +


submitted by cassdawg(1781), visit this page
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Orchiectomy will remove the testosterone stimulus prostatic cancer cells are dependent upon for growth and division. With removal of this stimulus, the cells will undergo apoptosis (scattered shrunken cells are apoptotic bodies).

The other answers are unlikely:

  • Corpora amylacea are small hyaline masses in the prostate gland of unknown significance. It would not be a change from normal to find these.
  • Edema is unlikely as this is more characteristic of diseases like prostatitis where inflammatory cytokines cause leaky blood vessels. Orchiectomy would not cause prostatic inflammation.
  • There is no stimulus for hypertrophy and rather with orchiectomy you are removing a growth stimulus.
  • Necrosis of the blood vessel walls is not likely because the blood vessels are not affected by the loss of the androgens, rather the actual prostatic cells are.
  • Widespread necrosis is also not likely as this is not the mechanism of death after testosterone removal (death will occur by apoptosis rather than necrosis) and widespread necrosis is more characteristic of infarct or something that causes massive sudden tissue death.
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dentist  so the MI detail is extraneous +1
fanderina  yeah i thought the answer was necrosis because of the MI +
chaosawaits  I also only chose necrosis because of the MI +
coco  this question ask which of the following microscopic changes in the prostate resulting from the ORCHIECTOMY is most likely present? +1


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