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cytotoxict
Alpha 2 agonists do not cause vasoconstriction b/c they lead to negative feedback of norepi and thus decrease sympathetic response
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sarahs
why is decreasing cAMP wrong?
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hiroshimi
@sarahs: you want to increase cAMP because it would lead to vasodilation and help to decrease his blood pressure. Decreasing cAMP would make his BP worse.
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fatboyslim
alpha2 stimulation causes vasodilation because it is sympatholytic.
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increase in cAMP (Gs) - beta2 - vasodilation
decrease in cAMP (Gi) - alpha2 - vasoconstriction
increase in IP3 DAG (Gq) - alpha1 - vasoconstriction
increase in cGMP - M3 - NO induced vasodilation