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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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cersnaie in PcAM )Gs( - 2ebat - ilvtoiandaos

srdceeea in cMPA i()G - h2lapa - rnivistconosctao

aisecner ni 3IP DGA G)(q - aah1lp - otncntiaosocvris

saeenric ni MPGc - 3M - NO idecdun itodnlasvoai

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cytotoxict  hpaAl 2 sstiaogn od ont ueacs oivcrcosatoinnst bc/ ethy aedl to enaviget afckebde of eoipnr and shtu dsecraee yahitpmscte sesrenop +1
payingforthisisdumb  0A2F 137p iฮฑtgnss-oa2 aneecrsi GPOM/Nc dan soadtvilae +
sarahs  why is girecansde MAcP wg?onr +1
hiroshimi  :as@hsar uyo tawn ot nreeicas PcMA acsebeu ti olduw adle ot ooinivdtalas adn lpeh ot edaersce shi dolob reeussr.p sDgcaniere PAcM uwdol mkae ish PB e.osrw +
fatboyslim  2ahpla tsiluoainmt cesusa dntavliooais aesbeuc ti si .palthmotsiycy +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)



 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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NHT nyeec,ermg uodiSm t.uipssiroderN Unlkei nlhazaydrie a anbacdle satlavrdoio in(ve = eltroiar)

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sympathetikey  Wlel htn,e I sseug we lshduo jtus gfetor taobu rou lod aspl eth lh-2apA agGo sotns.oid l.acl I d'tndi enev ees htta tsih saw ieevhtpyesrn yeneegm.rc mDbu on my .prta +
zup  os yea eicnnidol lowdu eb duse orf vpisyrntheee eynrcug, ubt hsti guy si vreo 108 120() os tehy ahve ot seu gtismneoh ikel nhidzyalare ro piiuosetrdrsn obht will esacrnie MGPc +
whoissaad  Dgsru edus to rtate NTH sngsneieLdovud Coepli:eiiaeridooyibilil comdNepen enlaaer ctilneapCpNdFrnmrt +18
lola915  anHylrzieda cluyaatl aestavsidol &;stgnsvtiairreee nda ousiseprdNitr ssaavdietol seirreat = si.nev othB csrieena .GMPc +12
vi_capsule  OS tshi eits egos earft ynemo own! ta stlae my cetsnmmo r'tane amesdrclb lol +2



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