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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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iscrnaee ni cPAM s()G - 2beat - sainoildavto

resdaece in AMcP i()G - h2apal - niascovorttnscoi

cirnesae in P3I GAD G)q( - ph1ala - toocannicosirvts

nerseaic in McPG - 3M - NO nucddie laisvtandoio

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cytotoxict  lapAh 2 soatgsin do ton uaces totrsnnoiaisovcc cb/ tehy lade ot iteeganv kbfaedce of eioprn dan shtu dseaeecr cahepstitym onresesp +1
payingforthisisdumb  A02F 713p gnaฮฑ-s2sito eisnecar NGM/OcP nda adaseitovl +
sarahs  hwy si gaensredic PMcA rngw?o +1
hiroshimi  sshra@a: you tnaw ot iseanrce cAMP beuseac it odlwu ldae ot ootliinvdasa dna phle ot edacsere shi oobdl ersspue.r Dascgneeri PMAc wluod make ish PB rwse.o +
fatboyslim  aaph2l masttoinliu scasue iiotolvsadna beeasuc ti is samyhtyl.tipco +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)



 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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HTN gernemc,ey uoSmdi Nstroeriu.pisd keinUl irylznhdaae a adenalcb lvaooraidts i(nve = rl)itaero

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sympathetikey  leWl en,ht I suegs we oldhus usjt tfoegr tuoba rou old laps eth Ap2l-ha dsaosGontigo. cl.al I dtd'in eenv see thta hsit wsa ipyneheesrvt ycereg.men uDmb no my pa.rt +
zup  os aey iinnldcoe lwduo eb sdue rfo epyhvntieser yenrcg,u btu thsi ygu si ervo 081 (10)2 os tyhe vaeh ot seu mgtohsnei ekli idrnhyaealz ro suotesiripdnr hobt lwil ecriasne PGcM +
whoissaad  grsDu udes to atert THN dcdrdCCv gi :illiintnpoiyn necooNabrdi mreeeFispeild neNtluaseiLplaeoee pnorma +18
lola915  aleazHnidyr laaylctu tosvaaiedls ni&rertas;igteevs dan irrosiuNstdpe laaotssvide rrsteiea = nive.s Bhot ereniacs P.GMc +12
vi_capsule  OS isth etis geos artef neomy !wno at sltea ym moetscmn n'trae samlecrbd oll +2



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