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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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acrneise in APMc )sG( - b2eta - vtndoilaiaos

sercadee ni cMPA i)(G - aah2lp - nosrisccvtnoiato

necrsaei in IP3 AGD (Gq) - p1hala - ionivtsccsrntoao

seraeicn ni McGP - M3 - NO eincdud ivataodnsloi

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cytotoxict  phlAa 2 iatosgsn do tno uscae tsrctninoosavico cb/ yhte dlea ot aeventig ekecdfab fo einpro and hsut eersacde tiscepmytha rsopesen +1
payingforthisisdumb  F02A p371 t2gao-siฮฑns ceeransi /ONGMcP adn lsteaovida +
sarahs  hyw is agiecnresd PMAc ngw?or +1
hiroshimi  h@s:saar uoy wtan ot ceserani PMAc seebuac ti oudwl eald to tsoaaodivnli nad hpel ot ecedrase sih lbdoo esur.rpse inesDagrce MPcA wdoul meak hsi PB wo.sre +
fatboyslim  a2plha iaotutismln saeusc tidnloaavsio suceeba it si ltyip.tmchyaos +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)



 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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THN ymrceg,ene oudSim otideuNsipr.rs lUenik ahilrzydena a lbnacead aivodoarslt i(vne = lroerit)a

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sympathetikey  llWe tnhe, I uessg ew sludho sutj roegft btaou our old lsap hte 2ph-Aal snog aoidost.G cll.a I ntddi' eenv ese htta sthi wsa ienyhrvpetse .eermnygec mDub on my rat.p +
zup  so yae ecoiidlnn odluw eb dseu fro eeviyhtrnpes rcyenug, btu sthi uyg si vroe 180 01()2 os heyt veha to use nogistmeh kile aehldayzrni or esrtisuindpro boht lliw eenrcasi cMGP +
whoissaad  usgDr sedu to aertt NHT adiFeeuanpiLreirtncoedgp:iplolc bpdleisaee oreivnCnCtmomdeiN rls ni ieyondNal +18
lola915  rlienHaazdy ylalautc eaosasitvdl aen&i;ergvsirttse dan iesstriordNup sdeiasatolv esriaert = .nevis oBht eesancri .cGPM +12
vi_capsule  OS tsih teis sego ftrea onmey w!on ta ltsea ym cmmenost 'neatr rmacsldeb llo +2



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