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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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sneecair in MAPc sG)( - t2bea - sildiotvnaoa

reacesde ni cAMP )(Gi - pha2al - tcososaciitnorvn

sneciear in I3P DAG G()q - alap1h - tcoaivstnicnoors

erasienc ni GPcM - M3 - ON ndcediu nadatosioivl

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cytotoxict  lahpA 2 tgisnoas od otn aescu nisncrtiaotsvooc c/b hyet ldea ot gevenati dkabeefc fo rnepio dna tuhs ereacesd ysptitmecah perensos +1
payingforthisisdumb  A0F2 p317 g-ฮฑ2sitsano iarneesc OGPMNc/ nda vtaisleoda +
sarahs  yhw si endcieagsr AMPc gro?nw +1
hiroshimi  ssha@:ar yuo ntwa ot eicarsne McPA ucaesbe ti woudl ldae ot tivnlasodaio and elph ot eedcsaer ihs bdool ssrp.uere ceDasirnge McAP ouwld kame shi PB owser. +
fatboyslim  hlaap2 oliauitsmnt aucses ilaasntovido esuceba it si othpsyyic.malt +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)



 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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NTH r,yenmegce idmSuo Nutorsder.siip leUnki yhnezadaril a lbadecna atlvodsoria v(eni = ti)roaerl

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sympathetikey  leWl e,nth I segsu we shuodl jsut tgfoer ouabt oru old lpsa the laAph-2 tsag.osGoodn i lc.la I did'nt neve ees ahtt tish was yvreehistnep .gyrmeeecn mbDu no my rtp.a +
zup  os eay celiiodnn ldowu be esud rfo peisytrnehve nyrue,gc tbu isht ugy si oerv 801 2)01( so they haev to seu oentmshig kiel ndilzaryhae or insursoirdtpe hotb illw eincrsea GPcM +
whoissaad  Dgrsu dues to eratt HNT ieirtvgaraNledo lNaediCpr miyer i:iseollp cbeemn ics inFdidpopLetlaonoCdeuennn +18
lola915  Hedarazilyn yutalcal vslasdtoeia aivt;tersirneg&es and uersNtiisrpod tsdsoealavi eitarrse = nisve. otBh reisance MPG.c +12
vi_capsule  SO ihts iest oges tfaer nmeoy wo!n ta aslte my snoemmct ta'enr acbdmerls oll +2



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