NBME 21 Increasing cGMP (NBME Answers)

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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP 🔍 / 📺 / 🌳 / 📖
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+9 upvote downvote
submitted by ∗divya(75)

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rnseceai in cPMA )sG( - atbe2 - onaasioivldt

rdceseea in AMPc )Gi( - lap2ha - ovsctnonisrcotai

eicesanr in 3PI AGD Gq)( - laa1hp - oinvaortnsccstio

esraniec ni MGPc - 3M - ON ndecdui laoisiantovd

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cytotoxict lhpAa 2 sgtsoani od not esuca oociisstanrtnvco c/b ehty aedl ot ienvgeat cdeafebk fo reponi and tshu ceresade mpctaiehtsy perneoss +1

payingforthisisdumb 02FA p317 2nαiogssat- ienrasce MNG/PcO nda asatvedloi +

sarahs why si dcieraegsn APcM ongwr? +1

hiroshimi s@a:rsha uyo tawn to cneireas McPA bceaues ti wuodl lade ot dviotsaoanli adn elhp ot reeacdse ihs obdol sersurep. isegacernD MAPc uoldw akme ish PB rws.oe +

fatboyslim p2hlaa ulstmiinota euscas ilnitaoavdos auebsec it si hlitmaysct.yop +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)

+1/- b1ackcoffee(115)

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+2 upvote downvote
submitted by ∗vi_capsule(21)

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NTH yg,cremnee oSimud surt.eropiisdN nilekU dahyznrlaei a enlcbada vlrostoaadi vne(i = ltori)are

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sympathetikey lleW ,hnet I ssueg we shdlou usjt oegrtf baout ruo lod lpas hte p-Aa2lh at gGs.iodsoon alcl. I di'dnt evne see htat hsit wsa vtinserpyehe eycmgenr.e uDbm on my .part +

zup os yea iciedlnno ludow eb euds rfo reyiehtnvspe unry,gce utb htis ugy is roev 810 (2)10 so tehy evah to seu mhoiesntg kiel nlaaehziyrd ro reiospdniurts obht lilw seceiran PMGc +

whoissaad sDrug sdeu ot atter NHT pnaiegdNidaibLlnerntr i ue spteccaeCielmevlalymenoFoioC one :irdNppesirdnildo +18

lola915 iaHlerdanzy ataluylc eidaostslav nrrv&;giesetetsia dna prrossieuNitd tvaissledoa rieersta = isnv.e othB saerniec Pc.MG +12

vi_capsule SO tsih iset geos ferat onemy ow!n ta teasl ym msmcoten t'aern bdemcrsla llo +2

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