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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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earecisn ni MPAc )(sG - 2btae - dlvosiianoat

esdecrea in MAPc ()iG - ap2hal - ostsnicroaicvnto

rnscaiee in I3P GDA ()Gq - lhpaa1 - ircnnsotoiotcasv

srieeanc ni GcMP - M3 - NO duicned tadlioonsvai

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cytotoxict  lhapA 2 astosing od ont uecsa noaioivctsrsntco cb/ tehy deal to eeantvgi bekefcad of roinep dna uhts sdeeraec tmyaieshpct speosern +1
payingforthisisdumb  A02F p713 sitg-asฮฑon2 sraecnie MO/PcGN adn seivldaota +
sarahs  yhw is sdereaincg McAP w?gnro +1
hiroshimi  @ssaa:hr ouy awtn ot eicsnrea PAcM ecsbeau ti wuold edla to iosiovlndata dan leph to aedscree his dbool sps.ureer ngseDeaicr AcPM uwold akme hsi PB oer.ws +
fatboyslim  laap2h oslutnimati usesac nlaaoivditso auebesc it si yyiltpocmh.tsa +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)


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 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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HTN ecr,mneyge uSmdio tspiei.drsuorN lenikU andelhizray a aebadncl otadvrlsaoi vi(ne = )elirraot

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sympathetikey  llWe ,hten I gessu we oldhsu stju efgotr tuabo our lod psal het ha2Alp- .nssaooG ogtdi .lalc I 'tnidd neve ese ttha shit asw tseirpeeyvnh genryem.ce Dbum on my part. +
zup  so yae oncdelini dulow be esdu rfo epvsiehyretn ygncr,ue tbu hsit gyu si vore 180 2)0(1 os heyt evha ot eus hosmignte leik aerayihzlnd or nrorpdeitsusi obht lwli isreeacn MPcG +
whoissaad  Dgsru ueds ot ttera TNH dibeanaciieLi:dni opltsdnNcmdvelo epomlFdra ge noras CoClunelNpreniptrieeiye i +18
lola915  aazinlHdyer laatcluy soliaaestvd tvesein&i;arsergt dan rsisdtpureNio olevsidaast reitrsae = .vnies Boht aeencrsi MGcP. +12
vi_capsule  SO hist etis oesg aefrt moyne ow!n ta telsa ym mnmesotc na'etr draclsbem oll +2


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