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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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airscnee ni cAMP G)(s - at2be - loaontiisdav

eracseed ni AcPM G(i) - alha2p - snocovriaotnstci

iraeensc ni I3P DAG ()Gq - 1ahpla - vcoiorasntisncto

saicreen in McPG - 3M - NO udidecn iioanoatslvd

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cytotoxict  Apalh 2 snsgtiao od ont auces rasiocnsointovct cb/ teyh alde to eevintga aefkbecd of oipern nda tush sdaeeerc stpycithame nsoerspe +1
payingforthisisdumb  2F0A 317p t-ฮฑsnsi2oag inaeesrc MPN/GcO adn idovsealat +
sarahs  yhw is recisagdne AMcP g?rown +1
hiroshimi  haars:s@ yuo nawt ot siacneer PcMA asecebu ti wuold eadl to istladaooinv nda pleh ot deesearc shi odlbo re.useprs neegDisrca APMc lowud aemk sih PB ewsr.o +
fatboyslim  l2hpaa iustnmaiolt cussae odatoiivnals saeuecb ti si lt.typoiamcyhs +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)


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 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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NHT egyreec,mn Sudmoi driopr.steNusi ilUnke ahdaeylrzni a lndbeaca iartoaolsdv nie(v = r)ietorla

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sympathetikey  elWl enth, I gessu we usoldh ujts tfogre aotub uro old slap teh h2plaA- sn dtsaooi.gGo .acll I tnid'd eenv ese atht hsti swa phverystenie g.yrmceeen mbDu on my ar.pt +
zup  os aye cildoenin dlowu be esud orf nyihpveseter renuy,gc tbu htis gyu si voer 810 021)( so hyte veah to esu tnhismgeo kiel adyrznelhai or epsorursidtin tobh lliw scraeine GPcM +
whoissaad  rguDs edus ot aertt NHT iodntlnaFCsibaolou pesneegeepalocaitmdL rvnyiNdiplo elidicNe: rprCemnndie ire +18
lola915  Hyniedlazra ctuyalal seadasvoitl vr;eganttieiesrs& adn isriterpdousN eovidtalssa eraitres = en.svi hotB ieneasrc .GMPc +12
vi_capsule  OS sthi site geos aertf eonmy on!w ta lseta my tomenscm t'rnea crsalmebd oll +2


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