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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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ireecasn in cAMP s)G( - teb2a - tiaianoosdvl

eeacsdre ni PcAM G)i( - l2aaph - voontancirscsiot

eiseacnr in P3I DGA G)(q - alha1p - toiastinsocnorcv

cnesiera in PGcM - 3M - NO cdiuend ovasdilaotin

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cytotoxict  plahA 2 gsontsai do ton ecusa icooctirsanostvn c/b ethy elda ot ngveteia cabfkede of epnrio nad huts rseadeec tetphmasicy neorsesp +1
payingforthisisdumb  02FA 371p tฮฑno2sg-sai nescirae NGPMcO/ nad tadaiseolv +
sarahs  yhw is rsdceigane MAcP rwn?og +1
hiroshimi  hs:ar@as yuo want to ienacser McAP uecsbae ti owdlu elad to aodvilstoani nda ehpl ot eeerasdc ihs dbool sr.espeur genaDreics PMAc ouldw aekm ihs PB .wrsoe +
fatboyslim  ha2lap muntoisliat csasue nlaosiidavto ecasueb ti si phc.iyltyastmo +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)


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 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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HNT eynge,rmce Sdmiuo srriispu.eodtN ekinUl aznrahledyi a bdcnaael vloraostiad (inev = aitolr)re

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sympathetikey  eWll ,nthe I usesg we duhosl ujst etfrog otbau our ldo apls eht A2-aplh s ootgGiosnd.a .lcla I 'ntdid nvee ese htat htis wsa nryeephviste eem.gynrce buDm no my .rpat +
zup  so eya edciilnno wuold be seud rfo ivenretpeshy gn,eryuc ubt sith yug si rveo 180 1)2(0 os hyet aevh ot ues ongisthme ielk nazdiyhlare ro sioitnurdersp both will erncaesi PMcG +
whoissaad  srDug sued ot reatt THN oiai uerapoClmgniorbdnrdFa mieeicoie ninteppae rcnp:eysseLn ldNodCvldiNlt elie +18
lola915  ndrHleyiaza atylacul stdaelsaivo t;itesrsgen&evria nad ipreNdroiutss tvdeaalsios eraiters = n.ievs Both iceaenrs MPcG. +12
vi_capsule  OS tihs tsei geos tfrae onyme now! at telsa my ecsmmton art'en rdsmcbale oll +2


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