NBME 21 Increasing cGMP (NBME Answers)

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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP 🔍 / 📺 / 🌳 / 📖
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+9 upvote downvote
submitted by ∗divya(75)

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rineecas ni PMAc (sG) - eb2at - sandotoiialv

dcsereea in AcPM )(iG - lapa2h - airsonovtccnstoi

seieancr ni IP3 GDA )qG( - hlaap1 - ioictroasncstnvo

crseiane ni PGcM - M3 - ON unecddi aodvstoaiinl

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cytotoxict hApal 2 sgsnaiot od tno escau osocavcinointstr b/c hyte alde ot evngteia badkceef fo onpire and uhst scraeeed atihctsypme enspeosr +1

payingforthisisdumb 20AF 17p3 2tiαas-gnos eicsenra PMO/NcG adn lvotaiased +

sarahs ywh si rcisedaegn PAcM n?ogwr +1

hiroshimi sh:a@ras ouy wnat ot cerenasi PcAM saebeuc it luwod adel to dotsvailioan nda lhep ot aedreesc his obdlo pue.srrse ecrinDgase AMcP uldow kmae sih PB e.rwso +

fatboyslim pal2ha suttlinioam uceass aosatnoilivd bsaecue it is l.pyottcsyimah +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)

+1/- b1ackcoffee(115)

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+2 upvote downvote
submitted by ∗vi_capsule(21)

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NTH gyenrem,ce mudiSo dNersitorisu.p ekUiln yahdelazrni a deaclnba aotvsilroda nive( = tlerr)oai

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sympathetikey Wlel etnh, I uessg we sldohu utsj tgoerf utboa uor lod pals eth apAl-2h .dsosGoniot ag la.cl I nid'dt even ees tath stih was heprstyenvie geeenmcy.r mDbu no ym pr.ta +

zup os aye eoidlnnci oldwu be uesd for eithnypsrvee ,uregncy tub hits uyg is ovre 108 012)( so heyt evah to sue seontgmih leik adrhilenzya or oessdntiiurpr htbo illw ircsaene cMPG +

whoissaad Dgsru deus ot rttea HTN oLtlpiemcoep eelougrardinymeaptCnl:vNoansnsiindi rdiaeeeideb rnlF piNldcoiCe +18

lola915 adyHlezarni lytacula vdstleoiaas se;etregrna&istiv and Niprutsdioers osdiealasvt ertsiare = ei.svn hotB ainceesr MPG.c +12

vi_capsule SO thsi tise gose etfar myeon !nwo ta eslat my etmcnsom rn'eta rdecabslm llo +2

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