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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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rcnsieae in PAMc s()G - atbe2 - naltidoiaosv

rcesadee ni cAMP )iG( - apa2hl - coiistvrasnotcon

esaneicr in 3IP AGD G)q( - hpa1la - oicotanrvstsocin

eeaicrns in GPMc - 3M - ON ndedciu ivianoosaldt

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cytotoxict  lahAp 2 sgintoas do ont caues soinocornsivttac b/c teyh dlea ot eavngeit bedkfcae fo rneipo dna tuhs asderece ypehasticmt ospnseer +1
payingforthisisdumb  02AF 713p 2asognits-ฮฑ neericas OMPN/cG nda tidsvaoeal +
sarahs  ywh is dgsnecaeir cPAM or?nwg +1
hiroshimi  s@a:shra oyu wnta to ceasenir PMcA uebcesa it louwd eald to nvdoolisitaa dna pehl ot cdaersee hsi blood esrp.ersu niesgDcrea AMPc woldu ekma shi PB .sorew +
fatboyslim  2lapah utstoamnlii ucasse laisnitdavoo eabusce it is actlsiy.phytom +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)


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 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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HTN ,ycmneeerg Siudmo reNtspirdo.sui eiUkln rdazehnyail a lacnbdae droolvaaits (neiv = itelor)ra

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sympathetikey  Wlle tnh,e I guess we hdusol tusj egfrto otbau rou odl plas teh a2hApl- d.oosiaGgstn o c.lla I i'ndtd vnee ees thta hits asw nitpesrheeyv gce.erneym mubD on my .rpat +
zup  os eay enlnoicdi duwol be sude rof vretsyepihen uenygrc, but ihts guy si rveo 801 )21(0 os yhet evah ot ues toignhmes elki arldinazyhe ro erpndtsruisio htbo lilw iacneres cPMG +
whoissaad  rsugD usde to retta THN lNvaiCdieipeeil:nCe n uopgenipdFdNo tnprmdienel Li rocoyaiisdrtosamnebcearl el +18
lola915  znryHealdia aatycull tseladvaios ;nergve&teiatsris nda pireuioNdtrss tdslavoeasi rsteiear = vsien. oBht aireesnc G.PcM +12
vi_capsule  SO tsih esit oges efatr mynoe !nwo at elsat ym senocmmt 'rtnea lacdemrbs llo +2


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