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NBME 17 Answers

nbme17/Block 0/Question#0 (6.7 difficulty score)
A 56-year-old woman develops a restrictive ...
Beta-Pleated sheet structureπŸ”

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submitted by cassdawg(957),

The Congo Red staining showing characteristic birefringence (usually described as apple green) is indicative of amyloid (FA2020 p212). Her findings are characteristic of secondary amyloidosis with serum amyloid A which can cause restrictive cardiomyopathy and nephrotic syndrome and is associated with rheumatoid arthritis.

Amyloid protein composition is misfolded aggregates of beta-pleated sheets.

cheesetouch  FA 2018 p218 +1  

submitted by prostar(2),

I just wanted to add that Helix-loop-Helix is an example of a DNA binding motif.

High hydroxyproline and multiple disulfide cross-links are for collagen protein.