NBME 17 Membrane lipid peroxidation (NBME Answers)

NBME 17 Answers

nbme17/Block 0/Question#0 (reveal difficulty score)
A 58-year-old woman is brought to the ...
Membrane lipid peroxidation 🔍 / 📺 / 🌳 / 📖
tags: pharm pathoma repeat

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submitted by ∗cassdawg(1779)

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zalzale96 Created an account just to up vote this answer +5

cheesetouch 1998 journal via google " Myocardial injury after cardiac surgery with cardiopulmonary bypass may be related to free oxygen radical-induced lipid peroxidation" +

peteandplop "Evidence suggests that reactive oxygen species (ROS) may play important roles in the pathogenesis in myocardial infarction [2]. Following ischemia, ROS are produced during reperfusion phase [3, 4]. ROS are capable of reacting with unsaturated lipids and of initiating the self-perpetuating chain reactions of lipid peroxidation in the membranes" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2274989/) +1

mittelschmerz Honestly the wording got me on this one. Great answer +

acerj Also, you can rule out a few of the options to help justify this. Post MI you expect necrosis, not apoptosis. Remember, apoptosis is suicide, and necrosis is MURDER! Cell swelling is a sign of cellular injury, not cell shrinkage. The heart will undergo coagulative necrosis, not liquefactive necrosis. Also, protease inactivation by cytoplasmic free calcium is kind of nonsensical to me. Free calcium is more likely to cause cell injury via caspases (a form of proteases amongst other things), which is why calcium is usually bound up inside healthy cells. +5

ownersucks This question presentation is exactly how Sattar said in pathoma Ch2. Raise in cardiac enzyme following reperfusion +

amy FA2020 305: Reperfusion injury: free radical and increased Ca influx--hypercontraction of myofibrils There is increased cytoplasmic free calcium ions, but it induces hypercontraction, no protease inactivation. +

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submitted by ∗j44n(141)

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submitted by ∗feochromocytoma(36)

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imgdoc You're mixing up two concepts here. This isn't necrosis, there is no inflammation occurring here. This is irreversible cell injury secondary to free radical damage. Cellular swelling is associated with reversible cell injury and wouldn't cause leaking of cellular contents. +

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submitted by sennachan8059(1)

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submitted by ∗namesthegame22(13)

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