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Retired NBME 17 Answers

nbme17/Block 0/Question#0 (reveal difficulty score)
35-year-old man is brought to the ED, fatigue ...
Activation of adenylyl cyclase ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: micro repeat

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submitted by โˆ—cassdawg(1781)
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He has Vibrio cholera, as indicated by the gram-negative comma shaped organism and "rice water" stool and travel history. Cholera toxin causes constitutive activation of adenylyl cyclase leading to increased cAMP, increased chloride secretion and extreme watery diarrhea (FA2020 p146)

(Organisms with exotoxins FA2020 p132)

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waitingonprometric  For Sketchy people--the army guy is wearing a "Ga"s canister on his belt (for G alpha subunit) and is reading a base cAMP map (for activation of Gs causes increased cAMP levels) +2



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