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NBME 17 Answers

nbme17/Block 0/Question#0 (reveal difficulty score)
A 75-year-old man comes to the emergency ...
Salicylate poisoning ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—cassdawg(1780)
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Ringing in his ears (tinnitus) combined with mixed metabolic acidosis-respiratory alkalosis is hallmark of aspirin overdose (salicylate poisoning) [FA2020 p486]

  • He is in metabolic acidosis (his HCO3- is also low)
  • He is in respiratory alkalosis (his PaCO2 is low)

You might be thinking - is the PCO2 low because compensation?

Use Winter's formula: PCO2 = 1.5(HCO3-) + 8 (+ or - 2)

1.5(19)+8 = 36.5 so he should have a PCO2 34.5 to 38.5

His PCO2 is 30 so he has cocominant respiratory alkalosis.

[Acid base and Winter's equation FA2020 p592]

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