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NBME 17 Answers

nbme17/Block 1/Question#24 (reveal difficulty score)
A 34-year-old woman with pyelonephritis has ...
Gentamicin ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—cassdawg(1780)
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Aminoglycosides (like gentamycin) are bactericidal via irreversible inhibition of the initiation comblex by binding the 30S subunit [FA2020 p191]

  • Amoxicillin is a beta-lactam antibiotic which works by binding and inhibiting penicillin-binding proteins (transpeptidases) and block cross-linking in the cell wall [p187]
  • Ciprofloxacin is a bactericidal fluoroquinolone which acts by inhibiting DNA gyrase (topoisomerase II) and topoisomerase IV [p195]
  • Erythromycin is a macrolide (the macrolides are ACE - azithromycin, clarithromycin, and erythromycin) which acts by inhibiting protein synthesis via bindind to the 50S subunit and preventing translocation (macroslides) [p193]
  • Sulfamethoxazole is a sulfonamide which acts by inhibiting dihydropteroate synthase therfore inhibiting folate synthesis [p194]
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