namesthegame22It's also the rate-limiting step in catecholamine synthesis.
Thus, Analysis of the CSF = decreased catecholamins means and HVA in patients with tyrosine hydroxylase deficiency. Dystonia comes from a dopamine deficiency. Treatment centers around the replacement of l-dopa.+
submitted by โnamesthegame22(13)
Tyrosine hydroxylase normally converts tyrosine to L-DOPA, the precursor to dopamine, norepinephrine, and epinephrine.
Tyrosine hydroxylase deficiency leads to decreased dopamine and consequent progressive dystonia.
A decrease in dopamine leads to a decrease in dopamine degradation products, such as homovanillic acid.