Meconium aspiration is a common cause of persistent pulmonary hypertension of the newborn because it can lead to pulmonary vasoconstriction, which can lead to decreased pulmonary blood flow that leads to a vicious cycle leading to increased right to left shunting and increased PVR
To help combat this pulmonary vasoconstriction, the infant should be treated with supplemental oxygen (increased/improved oxygenation leads to dilation of lung capillaries and decreased pulmonary vascular resistance)
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