NFKB is in its inactive state bound to IKB. As a part of the classical pathway, bacterial antigens bind to TLR and activate IKB kinase, (kinase phosphorylates)

• IKB is ubiquinated and degraded

• NFKB enters nucleus and synthesises the inflammatory stuff

Uw QID: 11955

Here is a simplified image of the NF-kappaB pathway. NF-kB is important in transcription of inflammatory genes. A lot of PAMPs (pathogen associated molecular patterns) and inflammatory signals lead to activation of NF-kB which in turn mediates a whole heck of a lot of immune-related responses.