The mainstay therapy for Hodgkin disease (aka Hodgkin lymphoma) is radiation. This can induce DNA mutations in any bone marrow nearby. If the mutation knocks out genes related to apoptosis, proliferation, DNA proofreading, or the like, malignancy could occur over time.
ploy901Also note that alkylating chemotherapeutic drugs increase the risk for leukemia and lymphoma years down the line too+6
cheesetouchAML section mentions risk factors incl radiation and alyklating chemo (FA18 p 420)+
submitted by ploy901(13)
The mainstay therapy for Hodgkin disease (aka Hodgkin lymphoma) is radiation. This can induce DNA mutations in any bone marrow nearby. If the mutation knocks out genes related to apoptosis, proliferation, DNA proofreading, or the like, malignancy could occur over time.