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NBME 17 Answers

nbme17/Block 0/Question#0 (reveal difficulty score)
A previously healthy 17-year-old girl is ...
Myoglobin ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—cassdawg(1780)
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The description cooresponds to rhabdomyolysis which is excessive breakdown of skeletal muscle tissue that can lead to excessive release of myoglobin into the blood which causes myoglobinuria and kidney damage. Rhabdomyolysis can be precipitated by overexertion (such as a triathalon) and commonly presents with weakness and muscle tenderness and may also present with shortness of breath due to fluid buildup in the lungs.

Rhabdomyolysis will present with elevations in creatinine kinase as well as myoglobin, but it is the elevated myoglobin which causes the symptoms and acute kidney injury as seen in this patient. Creatinine kinase elevation causes no toxic effects, even though it occurs, as reported here.

Here is another article about rhabdomyolysis as it is not covered in depth in First Aid.

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j44n  I went with my gut on this just base on the physical exam. But they did have elevated Hemoglobin in the urine as well and I know Dr. Golijan said you cant get that after a marathon. Does anyone know why hemoglobin is wrong? +2
prostar  hemoglobin is due to the breakdown of RBCs, not muscles. +
srmtn  During the dipstick test on a urine sample to evaluate for the presence of blood, the reagent on the test strip detects the presence of pigment in the urine sample. This pigment can be hemoglobin or myoglobin +1
ali_hassan  chose creatine kinase because i didnt know what a triathlon was and im proud +2
aditya_123  urine dipstick cannot differentiate between hemoglobin or myoglobin. therefore even if it is myoglobin, it shows positive for myoglobin. red urine or hemoglobin positive urine without rbc is indicating to myoglobin. +



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