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Retired NBME 15 Answers

nbme15/Block 2/Question#22 (reveal difficulty score)
A 22-year-old woman is found to be HIV ...
Protein processing ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—cassdawg(1781)
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The -navirs are protease inhibitors, so a mutation in protein processing would cause resistance.

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radzio1  in FA p203 it literally says Protease Inhibitors act by inhibiting maturation and assembly. So thats what I picked. Why is protein processing more appropriate? +2
radzio1  in FA p203 it literally says Protease Inhibitors act by inhibiting maturation and assembly. So thats what I picked. Why is protein processing more appropriate? +
kaf  maybe packaging means sending out of the cell? +
pakimd  on pg 203 of first aid it says protease inhibitors inhibit HIV-1 protease which cleaves polypeptide products of HIV mRNA into their functional parts; proteases are responsible for cleaving and processing proteins made from HIV RNA transcript into functional parts and protease inhibits this process by inhibiting proteases responsible for processing proteins that are made from HIV mRNA +1
pakimd  on pg 203 of first aid it says protease inhibitors inhibit HIV-1 protease which cleaves polypeptide products of HIV mRNA into their functional parts; proteases are responsible for cleaving and processing proteins made from HIV RNA transcript into functional parts and protease inhibits this process by inhibiting proteases responsible for processing proteins that are made from HIV mRNA +
pakimd  protease inhibitors* inhibit proteases +
pakimd  and then those functional proteins are assembled and packaged into virions to be released and infect other T cells +
pakimd  if you look at the illustration on pg 201 of FA youll see that they say that protease inhibitors inhibit proteolytic processing +1
cheesetouch  in a UW question I did, it said that protease inhibitors inhibit gag-pol cleavage, which would probably be considered a form of processing. gag -> p24 capsid and p17 matrix proteins pol -> reverse txase, aspartate protease, integrase pakimd makes a great point above about the img on 201. I think this is just kind of a crappy question LOL +
whk123  [Check here the image says that, sketchy pharma mentioned regarding pol gene too in regard of navirs] (https://basicmedicalkey.com/wp-content/uploads/2017/02/image01621.jpeg) => Here it comes +



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