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Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.
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ZDV used for general prophylaxis and and during pregnancy page 203 FA 2019
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NRTI's are associated with possible side effects of anemia, granulocytopenia, and myelosuppression.