NBME 20 X chromosome-linked isoenzymes (NBME Answers)

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NBME Answer Explanations

NBME 20 Answers

nbme20/Block 1/Question#40 (reveal difficulty score)
Monoclonality of neoplastic cells in ...
X chromosome-linked isoenzymes 🔍 / 📺 / 🌳 / 📖
tags: pathoma

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+35 upvote downvote
submitted by ∗hayayah(1212)

Neoplasia is new tissue growth that is unregulated, irreversible, and monoclonal.

Clonality can be determined by glucose-6-phosphate dehydrogenase (G6PD) enzyme isoforms. G6PD is X-linked.

*For more information check out Ch. 3 Neoplasia in Pathoma

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hello This is great, thank you. +5

breis Pathoma ch. 3 pg 23 "Basic Principles" +9

charcot_bouchard Shoutout to Imam Satter! Without him this question wasnt possible for me to answer in 10 sec. +19

fatboyslim Clonality can also be determined by androgen receptor isoforms, which is also present on the X chromosome (Pathoma Ch. 3 Neoplasia) +2

lovebug @fatboyslim thanks for reminding! +2

makingstrides Just to make sure I got this right, because this is neoplastic and its monoclonal, you want to look at the isozymes to determine its clonality? +2

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