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NBME 20 Answers




Question#4 (reveal difficulty score)
A 50-year-old man is brought to the emergency ...
Formic acid πŸ” / πŸ“Ί / 🌳

Question#5 (reveal difficulty score)
A 24-year-old African American man comes to ...
Pseudofolliculitis barbae πŸ” / πŸ“Ί / 🌳


Question#7 (reveal difficulty score)
A 5-year-old girl with AIDS develops a ...
Thymidine kinase πŸ” / πŸ“Ί / 🌳


Question#9 (reveal difficulty score)
A 50-year-old man is brought to the physician ...
Pick disease πŸ” / πŸ“Ί / 🌳



Question#12 (reveal difficulty score)
A 72-year-old woman with dysphagia is ...
Right kidney πŸ” / πŸ“Ί / 🌳


Question#14 (reveal difficulty score)
A 28-year-old man who is a migrant worker ...
Psoas major πŸ” / πŸ“Ί / 🌳


Question#16 (reveal difficulty score)
A 30-year-old woman with multiple sclerosis ...
Pons πŸ” / πŸ“Ί / 🌳

Question#17 (reveal difficulty score)
A 50-year-old woman comes to the physician ...
Drug effect πŸ” / πŸ“Ί / 🌳





Question#22 (reveal difficulty score)
A 38-year-old woman comes to the physician ...
Vagus πŸ” / πŸ“Ί / 🌳

Question#23 (reveal difficulty score)
A 34-year-old man who is HIV positive is ...
CD4+ T lymphocytes πŸ” / πŸ“Ί / 🌳

Question#24 (reveal difficulty score)
A 50-year-old man comes to the physician ...
Omeprazole πŸ” / πŸ“Ί / 🌳

Question#25 (reveal difficulty score)
A 25-year-old primigravid woman at 42Β weeks’ ...
Phosphoinositide hydrolysis πŸ” / πŸ“Ί / 🌳

Question#26 (reveal difficulty score)
Serum cholesterol concentrations are measured ...
16% πŸ” / πŸ“Ί / 🌳

Question#27 (reveal difficulty score)
A 53-year-old woman comes to the physician ...
Schistosoma mansoni πŸ” / πŸ“Ί / 🌳

Question#28 (reveal difficulty score)
A previously healthy 16-year-old girl comes ...
Trichomonas vaginalis πŸ” / πŸ“Ί / 🌳

Question#29 (reveal difficulty score)
During an experiment, an investigator ...
Lysine πŸ” / πŸ“Ί / 🌳

Question#30 (reveal difficulty score)
A 33-year-old woman comes to the emergency ...
Lunate πŸ” / πŸ“Ί / 🌳

Question#31 (reveal difficulty score)
A 66-year-old man has had fatigue, shortness ...
Focal pulmonary fibrosis πŸ” / πŸ“Ί / 🌳


Question#33 (reveal difficulty score)
A 17-year-old girl comes to the emergency ...
Mitochondrial πŸ” / πŸ“Ί / 🌳

Question#34 (reveal difficulty score)
A strain of Escherichia coli produces a ...
Missense πŸ” / πŸ“Ί / 🌳


Question#36 (reveal difficulty score)
A 56-year-old man is admitted to the hospital ...
Rhabdomyolysis πŸ” / πŸ“Ί / 🌳





Question#41 (reveal difficulty score)
A 45-year-old man has fever, chills, dysuria, ...
Escherichia coli πŸ” / πŸ“Ί / 🌳





Question#46 (reveal difficulty score)
A 55-year-old woman comes to the physician ...
Cholecalciferol πŸ” / πŸ“Ί / 🌳


Question#48 (reveal difficulty score)
An otherwise healthy 4-month-old girl is ...
Spontaneous involution πŸ” / πŸ“Ί / 🌳


Question#50 (reveal difficulty score)
A 26-year-old man undergoes an abdominal ...
Splenic πŸ” / πŸ“Ί / 🌳


Question#2 (reveal difficulty score)
Following a wedding reception that was ...
Norovirus πŸ” / πŸ“Ί / 🌳

Question#3 (reveal difficulty score)
An investigator compares the DNA sequences of ...
5β€² CCGG πŸ” / πŸ“Ί / 🌳



Question#6 (reveal difficulty score)
An 18-year-old boy has just been diagnosed ...
50% πŸ” / πŸ“Ί / 🌳


Question#8 (reveal difficulty score)
Three elderly residents of an assisted living ...
Legionella pneumophila πŸ” / πŸ“Ί / 🌳

Question#9 (reveal difficulty score)
An otherwise healthy 16-year-old girl comes ...
Cold, dry air πŸ” / πŸ“Ί / 🌳



Question#12 (reveal difficulty score)
An 80-year-old man with type 2 diabetes ...
Pelvic splanchnic πŸ” / πŸ“Ί / 🌳



Question#15 (reveal difficulty score)
A 55-year-old man comes to the physician ...
Dextromethorphan πŸ” / πŸ“Ί / 🌳



Question#18 (reveal difficulty score)
A 65-year-old man is brought to the emergency ...
ST-segment elevation πŸ” / πŸ“Ί / 🌳

Question#19 (reveal difficulty score)
A 66-year-old man is brought to the emergency ...
Cigarette smoking πŸ” / πŸ“Ί / 🌳

Question#20 (reveal difficulty score)
A 19-year-old man who is a college student is ...
Subcutaneous crepitus πŸ” / πŸ“Ί / 🌳


Question#22 (reveal difficulty score)
A 44-year-old woman comes to the physician ...
Ubiquitin ligase πŸ” / πŸ“Ί / 🌳


Question#24 (reveal difficulty score)
A patient with a 1-week history of diarrhea ...
Decreased arterial Pco2 πŸ” / πŸ“Ί / 🌳




Question#28 (reveal difficulty score)
At a postnatal checkup, a 6-week-old female ...
Annular pancreas πŸ” / πŸ“Ί / 🌳

Question#29 (reveal difficulty score)
A 25-year-old woman has a flu-like illness ...
Picornavirus πŸ” / πŸ“Ί / 🌳

Question#30 (reveal difficulty score)
A 78-year-old man is brought to the emergency ...
Cortisol πŸ” / πŸ“Ί / 🌳


Question#32 (reveal difficulty score)
A 12-year-old girl is brought to the ...
Osteoblasts πŸ” / πŸ“Ί / 🌳

Question#33 (reveal difficulty score)
A study is conducted to assess the effect of ...
Lead-time πŸ” / πŸ“Ί / 🌳

Question#34 (reveal difficulty score)
A 28-year-old man has excessive thirst and ...
Hypothalamus πŸ” / πŸ“Ί / 🌳

Question#35 (reveal difficulty score)
A 36-year-old woman comes to the office ...
Splenomegaly πŸ” / πŸ“Ί / 🌳

Question#36 (reveal difficulty score)
A 31-year-old man has a large, yellow, soft ...
Liposarcoma πŸ” / πŸ“Ί / 🌳




Question#40 (reveal difficulty score)
A 70-year-old man has a 3-month history of ...
Squamous cell carcinoma πŸ” / πŸ“Ί / 🌳


Question#42 (reveal difficulty score)
A previously healthy 32-year-old woman is ...
Preload πŸ” / πŸ“Ί / 🌳

Question#43 (reveal difficulty score)
An 18-year-old woman comes to the physician ...
Ovaries πŸ” / πŸ“Ί / 🌳


Question#45 (reveal difficulty score)
A new antiplatelet agent is developed for the ...
8% πŸ” / πŸ“Ί / 🌳


Question#47 (reveal difficulty score)
A 35-year-old man comes to the physician to ...
1:4 πŸ” / πŸ“Ί / 🌳

Question#48 (reveal difficulty score)
A sedentary 50-year-old man with hypertension ...
Antidepressant therapy πŸ” / πŸ“Ί / 🌳


Question#50 (reveal difficulty score)
A 27-year-old woman comes to the physician ...
Pheochromocytoma πŸ” / πŸ“Ί / 🌳

Question#1 (reveal difficulty score)
The frequency of an autosomal recessive ...
1/25 πŸ” / πŸ“Ί / 🌳

Question#2 (reveal difficulty score)
A 23-year-old woman is brought to the ...
Xanthine oxidase πŸ” / πŸ“Ί / 🌳

Question#3 (reveal difficulty score)
A 45-year-old woman has a thyroidectomy ...
Calcitonin πŸ” / πŸ“Ί / 🌳

Question#4 (reveal difficulty score)
An 18-year-old woman comes to the physician ...
Reactive T lymphocytes πŸ” / πŸ“Ί / 🌳

Question#5 (reveal difficulty score)
A 35-year-old man comes to the physician ...
Methotrexate πŸ” / πŸ“Ί / 🌳


Question#7 (reveal difficulty score)
A 10-year-old boy has a palpable mass in the ...
Endoderm of foramen caecum πŸ” / πŸ“Ί / 🌳


Question#9 (reveal difficulty score)
A 62-year-old man comes to the physician ...
Prostate πŸ” / πŸ“Ί / 🌳

Question#10 (reveal difficulty score)
A 59-year-old man develops fatigue and ...
Hemolysis πŸ” / πŸ“Ί / 🌳


Question#12 (reveal difficulty score)
A 46-year-old man has dyspnea, orthopnea, and ...
Mitral regurgitation πŸ” / πŸ“Ί / 🌳

Question#13 (reveal difficulty score)
A 45-year-old woman develops proteinuria and ...
Tubulointerstitial nephritis πŸ” / πŸ“Ί / 🌳


Question#15 (reveal difficulty score)
A 23-year-old woman, who was diagnosed with ...
Substance P πŸ” / πŸ“Ί / 🌳



Question#18 (reveal difficulty score)
An 18-year-old woman comes to the physician ...
50% πŸ” / πŸ“Ί / 🌳


Question#20 (reveal difficulty score)
A 67-year-old woman comes to the physician ...
Low sensitivity πŸ” / πŸ“Ί / 🌳






Question#26 (reveal difficulty score)
A 3-month-old boy is brought to the physician ...
Mannose 6-phosphate πŸ” / πŸ“Ί / 🌳

Question#27 (reveal difficulty score)
A 55-year-old man with type 2 diabetes ...
Pravastatin πŸ” / πŸ“Ί / 🌳

Question#28 (reveal difficulty score)
A 23-year-old woman who is 6 months pregnant ...
Antiplatelet antibodies πŸ” / πŸ“Ί / 🌳



Question#31 (reveal difficulty score)
A 62-year-old woman comes to the physician ...
Ξ²-Tubulin πŸ” / πŸ“Ί / 🌳

Question#32 (reveal difficulty score)
A 54-year-old woman with terminal metastatic ...
Nonmaleficence πŸ” / πŸ“Ί / 🌳




Question#36 (reveal difficulty score)
A 4-year-old boy has had fever, abdominal ...
Shigella sonnei πŸ” / πŸ“Ί / 🌳

Question#37 (reveal difficulty score)
A 62-year-old man with alcohol-induced liver ...
Spironolactone πŸ” / πŸ“Ί / 🌳

Question#38 (reveal difficulty score)
A 23-year-old man with a 3-year history of ...
Psychogenic polydipsia πŸ” / πŸ“Ί / 🌳



Question#41 (reveal difficulty score)
A 2-year-old child undergoes resection of the ...
Increase in glomerular size πŸ” / πŸ“Ί / 🌳

Question#42 (reveal difficulty score)
A 13-year-old girl has an episode of severe ...
Epstein-Barr virus genome πŸ” / πŸ“Ί / 🌳

Question#43 (reveal difficulty score)
A 71-year-old man comes to the physician ...
Cilostazol πŸ” / πŸ“Ί / 🌳


Question#45 (reveal difficulty score)
A 39-year-old man reports bright red spots on ...
Constipation πŸ” / πŸ“Ί / 🌳


Question#47 (reveal difficulty score)
A 60-year-old woman has prolonged apnea ...
Succinylcholine πŸ” / πŸ“Ί / 🌳

Question#48 (reveal difficulty score)
A 48-year-old woman comes to the physician ...
Hypothyroidism πŸ” / πŸ“Ί / 🌳

Question#49 (reveal difficulty score)
A 92-year-old woman who was recently admitted ...
Atrophy of dermal collagen πŸ” / πŸ“Ί / 🌳



Question#2 (reveal difficulty score)
A study is conducted to identify healthy ...
Liver πŸ” / πŸ“Ί / 🌳

Question#3 (reveal difficulty score)
A 23-year-old woman comes to the physician ...
Collagen synthesis πŸ” / πŸ“Ί / 🌳

Question#4 (reveal difficulty score)
A 20-year-old man comes to the physician ...
Olfactory πŸ” / πŸ“Ί / 🌳


Question#6 (reveal difficulty score)
A 51-year-old man develops diaphoresis, ...
Alcohol withdrawal πŸ” / πŸ“Ί / 🌳

Question#7 (reveal difficulty score)
A 33-year-old woman with HIV infection is ...
Non-Hodgkin lymphoma πŸ” / πŸ“Ί / 🌳

Question#8 (reveal difficulty score)
A 58-year-old man is brought to the emergency ...
Hypertension πŸ” / πŸ“Ί / 🌳


Question#10 (reveal difficulty score)
A 65-year-old woman who has a 25-year history ...
Hydroxylation of proline πŸ” / πŸ“Ί / 🌳

Question#11 (reveal difficulty score)
A 37-year-old man who is HIV positive comes ...
Nortriptyline πŸ” / πŸ“Ί / 🌳


Question#13 (reveal difficulty score)
A 62-year-old woman comes to the physician ...
Bronchogenic carcinoma πŸ” / πŸ“Ί / 🌳




Question#17 (reveal difficulty score)
A previously healthy 55-year-old man has ...
Renal artery stenosis πŸ” / πŸ“Ί / 🌳

Question#18 (reveal difficulty score)
A 35-year-old man comes to the physician ...
Gastrin πŸ” / πŸ“Ί / 🌳


Question#20 (reveal difficulty score)
A 5-year-old boy is brought to the physician ...
Hypophosphatemia πŸ” / πŸ“Ί / 🌳

Question#21 (reveal difficulty score)
A 47-year-old woman comes to the physician ...
Contact with parakeets πŸ” / πŸ“Ί / 🌳





Question#26 (reveal difficulty score)
A 33-year-old man comes to the physician ...
Rectus femoris πŸ” / πŸ“Ί / 🌳

Question#27 (reveal difficulty score)
An investigator is studying patients with ...
Case series πŸ” / πŸ“Ί / 🌳


Question#29 (reveal difficulty score)
A 15-year-old girl is brought to the ...
Doxycycline πŸ” / πŸ“Ί / 🌳


Question#31 (reveal difficulty score)
A 48-year-old man is brought to the emergency ...
Cl-: 96 mEq/L; HCO3-: 8 mEq/L πŸ” / πŸ“Ί / 🌳


Question#33 (reveal difficulty score)
A 65-year-old woman with cardiovascular ...
Increased bile salt πŸ” / πŸ“Ί / 🌳


Question#35 (reveal difficulty score)
A 62-year-old man comes to the physician for ...
Contemplation πŸ” / πŸ“Ί / 🌳


Question#37 (reveal difficulty score)
A 16-year-old girl with cystic fibrosis is ...
Vitamin E πŸ” / πŸ“Ί / 🌳

Question#38 (reveal difficulty score)
A 45-year-old man comes to the physician ...
Tumor necrosis factor πŸ” / πŸ“Ί / 🌳

Question#39 (reveal difficulty score)
A 30-year-old woman develops serum sickness ...
C3a πŸ” / πŸ“Ί / 🌳


Question#41 (reveal difficulty score)
A 56-year-old man with a 20-year history of ...
Naloxone πŸ” / πŸ“Ί / 🌳

Question#42 (reveal difficulty score)
A 65-year-old woman dies 6 months after the ...
Meningeal πŸ” / πŸ“Ί / 🌳


Question#44 (reveal difficulty score)
A 45-year-old man comes to the office for ...
Starchy foods πŸ” / πŸ“Ί / 🌳


Question#46 (reveal difficulty score)
A 28-year-old woman at 32 weeks' gestation ...
Obstructive uropathy πŸ” / πŸ“Ί / 🌳


Question#48 (reveal difficulty score)
A 24-year-old man comes to the emergency ...
Lipoprotein lipase πŸ” / πŸ“Ί / 🌳



Recent comments ...

... amorah made a comment on nbme20/block3/q#35 (A 51-year-old man has the acute onset of fever and...)
 +40 
submitted by amorah(105)
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reFev g&t-; lrue otu elft rartcleivnu ailfure T-SMXP M rhpxoyiaslp ;-&tg erlu uot snPyitemousc deireicnKovi jy nalsttnarp tbu on WRBC/CB ni unrie -tg&; relu uot tnnraplsta otecnjrei

vLenagi VCM dan altpicya umemraotcibyc as the gneamnrii wot pn.ostoi VCM is emor lekyli ni a lnpnatrsat ip.nttea

... hayayah made a comment on nbme20/block1/q#40 (Monoclonality of neoplastic cells in endometrial...)
 +35 
submitted by hayayah(1169)
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lseioaNpa is wen suitse trwgoh atht is dalger,tuenu brreierl,ives adn al.nmlnooco

yiltloaCn cna be deiemdrten yb oh6ae-h-gssclptoupe yeogrhnesdeda )D6(GP nzeeym osmrfso.i D6GP si lekdi-Xn.

*For moer inintaoofrm hkecc out hC. 3 aapelosiN in Phaoamt

hello  This is great, thank you. +5
breis  Pathoma ch. 3 pg 23 "Basic Principles" +9
charcot_bouchard  Shoutout to Imam Satter! Without him this question wasnt possible for me to answer in 10 sec. +16
fatboyslim  Clonality can also be determined by androgen receptor isoforms, which is also present on the X chromosome (Pathoma Ch. 3 Neoplasia) +2
lovebug  @fatboyslim thanks for reminding! +1
makingstrides  Just to make sure I got this right, because this is neoplastic and its monoclonal, you want to look at the isozymes to determine its clonality? +2
... hayayah made a comment on nbme20/block3/q#44 (A 56-year-old man is brought to the emergency...)
 +35 
submitted by hayayah(1169)
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VL despopt kwg,nroi rsrpusee dcbkae pu inot uplm itccri.u luPm icrituc yhgurol is amde fo 3 ra"tps" - the iaarplisec,l tetlaniiitrs sca,pe adn hte ilelva.o

nI denaocgiric ohk,cs het xaetr olbdo aiesernsc ilyarapcl htiscdorayt euepsrsr, rdgvnii idluf otin the ieistlnttrai psac.e amdperoC ot eht vlale,io teh ltsiieiatnrt sepca nwo sah moer iufdl hst(u eomr itstariliten sthiraotycd urssreep dan essl iotnocc sesuperr edu to ariot fo uilfd to otp,n)eir and as a tuersl fo itsh gnaiucnabnl of ofcers, udlfi somev oint the lielaov gt&--; auromnylp .daeem

... masonkingcobra made a comment on nbme20/block4/q#21 (A 47-year-old woman comes to the physician because...)
 +33 
submitted by masonkingcobra(384)
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Paeg 2 ash a getra uicpetr

pdrn6loli-hS2ectj91ra7//91go0.08ne06)s(3/iwcit.tw6aw//f-p14:

kamilia20  chlamydophila psittaci?? +1
... hayayah made a comment on nbme20/block2/q#32 (A 12-year-old girl is brought to the physician by...)
 +30 
submitted by hayayah(1169)
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A bgi tginh reeh oto is ioingtcn that eth PLA si .desraeedc oOtstlaebs civayitt si mrsedeau yb ebon A.LP I htkni htat was the niam cfsou ereh and not htat you enacesirlsy nede to onkw eht FCB1A geen n.imoattu

sympathetikey  Exactly. That's the only way I got to the answer. +4
pakimd  isnt increased alk phos consistent with increased osteoblastic activity? +
champagnesupernova3  A defect with chondrocytes would cause an short limbs like in achondroplasia so those are ruled out +1
pg32  Exactly. Can also be helpful if you remember that the clavicles are formed by intramembranous ossification rather than endochondral; that allows you to rule out the chondroblast/cyte answer choices. +7
... medbitch94 made a comment on nbme20/block3/q#26 (A 3-month-old boy is brought to the physician...)
 +30 
submitted by medbitch94(50)
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912F0A apeg :74 ll-Iec assdeie sli(nnoiuc lcel ddissiisosu/pocilemae tyep tβ€”hieeII)rdni aoossllym ogstrae rer;odsdi eeftdc in oe1nicgphl-alacal-yuaNtry-fpsrhenmesoosst r;r&ar rufaile of het ogGil to hhoypterploas namnseo iesruesd g(fnrmio en)t6saepsoo-h-anmph no nsgoopryctlei ;rra&r isetprno ear ctedesre uxararlllcleety eartrh nath lreediedv to yemos.lsso essutRl in sacero caifla efseuta,r nvligaig pp,ayhlsiare ldocdue ,nasreco ircedretts ijotn ,tesnmomev lwac ndha doreti,ifems ,yihsslpkiooosc dna hihg lpaasm vllsee fo aolysomls esynz.me enftO aaltf ni iodld.ohch

athenathefirst  FA page 47 +
... hello made a comment on nbme20/block3/q#44 (A 56-year-old man is brought to the emergency...)
 +29 
submitted by hello(397)
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at'snePti somsmtyp nbaeg 03 mni ferat nomiwg waln ei.(. ertaf gdnio sachlpyi y.ia)vtict eH ash sreeve cehst aipn adn is cloo, ,mycalm ioridhec.atp eH sah dancrseei oympanulr ayertr prresues nda edraseicn fetl trilaa .esrsuerp keTan lgtrtee,aho ihts is occrainegid s.okhc

geocaCdniri khcso is a rheta mupp meorpbl -- hte LV tsi'n kg.inwor

ehnW eht L,V 'tsni igrkonw, it asecsu a bkca pu in eht niteoricd etpsioop ot owh blood mnalloyr o.lfws h,rTfeeeor dolob wlli ckba up in hte ugln.s

Tshi usseca ceerdsnai aciplylra icyhtasrdot reeursps g-&t-; this diresv roem lfiud oint het esitumrtinti -&-;gt thsi escsau sndiacere ialitirtsetn catydthsrio ueerrssp -t-;&g eterh si won rmeo iuldf hnta rmolan in hte titmntriuise t--;&g isth feasctf the ipoertn airot itnwih eht rtuinmittes g--t&; thsi cussea reaecddse etnlaistiitr ctniooc psesreur.

targetusmle  awesomely explained :) +
lilyo  This was amazingly explained Thank you @Hello! +
pseudopseudopth  For edema to occur shouldn't interstitial oncotic pressure be increased?(when proteins are there, they can pull the fluid) +1
pseudopseudopth  And when increased interstitial hydrostatic pressure is pressure, shouldn't it oppose the edema by pushing against it? +1
pseudopseudopth  *when interstitial hydrostatic pressure is increased +2
pmofmalasia  You don't necessarily need to have increased oncotic pressure, you're correct in that decreased oncotic pressure would act against causing edema but as long as the net change in forces still acts "for" edema it will still occur. For example in this scenario, if the capillary hydrostatic pressure is greater than the change in interstitial hydrostatic and oncotic pressures. Also, the change in interstital hydrostatic and oncotic pressures is a direct result of the edema in this scenario, so it's more like they're responsible for setting the new equilibrium - if they didn't counteract it, you'd never come to a point where the leakage of fluid stops. +
kcyanide101  Hey guys please help me affirm.... so based off your explanation, if it were hypovolemic chock.... capillary Hydrostatic pressure will drop, due to blood loss... interstitial hydrostatic Pressure will drop as fluid will move into the capillaries to balance things out and interstitial oncotic pressure will increase due to fluid loss from the interstitium.... IS THIS CORRECT? tnx +
... imgdoc made a comment on nbme20/block4/q#20 (A 5-year-old boy is brought to the physician for a...)
 +28 
submitted by imgdoc(160)
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Yuo can orcss uot eht pto eetrh sanrwe ,eihoccs ,.,BCA oYu town be rsbbgoerina ngnayhit ni hte PTC in cn'ifnaso sm.ryeodn gnoLkoi ta eih,oapylkma anhryetiopa,m dan oyahhpmpeospthai nw.o pkamoyalHei tcna' eb rorctec bsecaue enev gotuhh ptasiomus si slot it illw be drbseobare at hte raelt iktch nandgcise opol dan if htta tdsone emka ,seens the ybod lilw atdujs fro wlo semru mosptaisu tbu iatcvgatni eth /+K+H mupp no c.lsle tI s'int npoyhemitara sbcauee ta het gienolcctl duct ilpanpcir ,lcesl ptirbraoseon wlli ucocr. Tsih evsael otioeyaahhmpphps sa hte coercrt dan olyn nswera eh.oicc

imgdoc  by* +2
larascon  Excellent explanation, thank you ! +2
waterloo  It's worth mentioning, that 25% of Na is reabs in the thicc ascending limb. 67% of filtered Na is reabsorbed in the PCT, whereas 85% of phosphate reabsorbed in the PCT. So pt more likely to show Hypophos. +3
coconut  UWorld QID:7626 says lab results in people with Fanconi syndrome will show hypokalemia +
j44n  coconut i thought that too but then i remebred fanconi is associated with hypophosphatemic rickets/ VIT D resistant rickets and this little dude is going to be growing because he's 5 and thats gonna increase the demand for phosphate in his body +
... celeste made a comment on nbme20/block2/q#6 (An 18-year-old boy has just been diagnosed with...)
 +27 
submitted by celeste(88)
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Wheil eht imelftei srik ni teh lregnae lpntouaopi is tjsu elobw %1, ti is 5%6. in eetdirseg-rf isetvlera fo iaettspn dna ti ierss to emro tnah 0%4 in gmtincozyoo siwnt of ftedecfa plo.epe nayliAzgn lccssai ssdueit fo het ngcieste of ihrnaiphezosc noed as rylea as ni s,0931 rhesFic ncdlcueso hatt a rcdcoocnaen trea rof sshcsopiy of otabu 50% in nziomyctogo nwits emsse ot eb a iralcesti mstteia,e ciwhh si yncgisalnfiit erhhgi anth hatt ni idgoyzcit nwsit of otabu 1–%901 (oil.irngn3#Mm2vp//ae36ibcmlen/f/56.rch4P9tCs.c)

imnotarobotbut  How is one supposed to know this before having read this article? +36
imgdoc  This question falls under the either you know it or you dont category. It isnt in FA or Uworld +2
jaxx  So why would these A-holes put it on there as if prepping for this exam isn't stressful enough :-| +9
doodimoodi  Lol just why seriously +3
champagnesupernova3  This was mentioned in the Kaplan behavioral videos +
usmlecrasher  and there's so much unnecessarily BS instead of real questions +3
j44n  I'm just glad we're seeing this garbage now instead of having an aneurysm in the prometric center +7
feanor  This Question is a perfect example of where you just jump off your seat to demand a refund or you decide to go Antisocial Disorder on your computer screen. +
olddoc  I don't think it has to do with any extra info. The dx is FAP (mutation in APC gene) which is inherited in an AUTOSOMAL DOMINANT fashion ("A" is the mutant allele and "a" is the normal one. The girl in the question stem MUST be heterozygote "Aa", getting the mutant "A" from her sick father and "a" from her healthy mother. Assuming she marries a healthy husband (aa) (this is a normal assumption in genetics questions), their kid will be Aa (the phenotype that will 100% result in CRC) by a probability of 50%. Recall that FAP will 100% progress to CRC is not prophylactically removed. +3
olddoc  FA 2019 Page 381 +
conniea168  It sucks because in psychiatry rotation as MS3 you may come across this fact that rate is ~50% in identical twins, but other than that it's unfair for Step 1 :/ +
... hayayah made a comment on nbme20/block1/q#34 (A strain of Escherichia coli produces a...)
 +26 
submitted by hayayah(1169)
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sneseisM tiunmsaot vlnveoi a iolntcedeu nbouuttsisit nustgreil ni enaghdc aimon .iscda mioSmeste eht fecsfte of nesesmsi iomnttaus amy eb lnyo tenarapp dnuer raeintc vteneimnnrlao od;nitnsoic hscu eneissms usnaiotmt rae ldecal aolndnciito amton.itsu nayM imessnse unsmaoitt leutrs in irposent thta ear itlsl nl,fanoticu ta laset ot msoe d.geere

ls,oA lal eht herto wnasesr wduol ybbralop leave uyo thwi hrteie a rygtlae aerledt ro onftcnl-nouian iotn.rpe

thefoggymist  I chose nonsense because I thought it'll make the enzyme shorter (since less bonds = more heat liable = can't work at 42 degrees) but yea, probably won't work even at 30 if it's an early nonsense. +11
joanmadd  A good clinically related example is HbC disease on electrophoresis. HbC disease is due to a missense mutation (glutamic acid (-) for valine (neutral)). The mutated hemoglobin is still fairly functional but when placed on gel electrophoresis the HbC migrates the least far from the negative electrode due to less negative propulsion (lack of wild type glutamic acid). +3
fatboyslim  @Joanmadd Just to clarify, glutamic acid substitution for valine occurs in sickle cell disease not HbC. HbC is glutamic acid substitution for lysine :) +8
rockodude  lyCCCCine for HbC +3
l0ud_minority  I was thinking this was r/t a transposon inserting itself in DNA. +
... strugglebus made a comment on nbme20/block1/q#17 (A 50-year-old woman comes to the physician because...)
 +25 
submitted by strugglebus(181)
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horNeew eavh I nbee bela ot dnif hyw eth ellh hsti is a gh.nit

yotsubato  Its not in FA, Sketchy, or Pathoma, or U world. I knew it wasnt cancer because its bilateral. And Diabetes made no sense to me. So I just threw down Drug effect and walked away. +7
breis  same^^^ +
feliperamirez  The only possible explanation I think is that she was under a K sparing diuretic, such as spironolactone (which would lead to gynecomastia). +
chandlerbas  you had me at its not in sketchy ;) +3
j44n  i thought HTN induced empty sella would cause this because they got type II diabeetus. So if you need a pro zebra hunter holler at me. +
... andrewk1 made a comment on nbme20/block2/q#9 (An otherwise healthy 16-year-old girl comes to the...)
 +25 
submitted by andrewk1(25)
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sThi gilr sha eeiecxrs decundi .amasht It is ton ellw urtonosedd ywh it phapens tub hte terggris are zidorcege.n almlyorN when inghtbear ocuscr ira is ktnea in yb the oens adn the slnaa spasseag and ttuanibrse tac to emrvoe sdut dna iaimm/dywfhru hte ari. ollcaiygL isht aeskm het air dnseer =.TRPvn So enhw niigcees,xr inrgbehat hotghru the sone is edadrsece adn dapecerl yb remo vooiusrg uhtmo hagi.netbr hsTi ansme the air is ton ddiiihmfue nad dmwear .up eTh ari is lsse dsnee nda eth mahtsa .sesneu ehT nuistoeq toko isth maes eirplpicn ptxeec vdreesre ti yb asgkin athw exrtlane oitcnnoid lcdou lead to hte tmhaas dan that dulow eb odlc yrd ri.a

eacv  oooh thank u !!! I choose wrong, cold air hehhe +6
eacv  moisture air instead! +


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