Iron overdose is a cause of a high anion gap metabolic acidosis.
meningitisI found this to add a little bit more explanation as to how it causes the acidosis if anyone needs it.
1. Mitochondrial toxicity - decreases aerobic respiration and shunts to lactic acid production
2. Cardio toxicity (Secondary to Mitochondrial toxicity) leads to cardiogenic shock (hypoperfusion), which causes lactic acidosis
3. Hepatotoxicity - Decreases lactate metabolism, causing lactic acidosis
4. When in trivalent form (Fe+3), it can react with 3 molecules of H2O
--> FeOH3 + 3H+
This will then deplete Bicarb buffering system resulting in non-gap acidosis.
Source: https://forums.studentdoctor.net/threads/iron-poisoning-anion-gap-or-non-anion-gap-acidosis.958285/+72019-05-28T04:04:50Z
sympathetikeyNone of the other choices were even metabolic acidosis. They threw us a bone with this one.+2019-05-31T23:40:14Z
imnotarobotbutDon't changes in bicarb take a few days? How did his bicarb drop down to 8 in 12 hours?+2019-07-07T16:05:27Z
to snoo-finity ... and beyond!
submitted by hayayah(349), 2019-05-16T15:53:45Z
Iron overdose is a cause of a high anion gap metabolic acidosis.