There is an abnormally decreased function of the hydroxylation of proline because the 2nd stage in collagen synthesis (hydroxylation of specific proline and lysine residues) requires vitamin C. Since this patient has Scurvy (vit. C deficiency), this process is unable to occur.
FA19, pg 69 - perifollicular and subperiosteal hemorrhages, pg 674 specifically lists mucosal bleeding
Wouldn't chronic alcoholism also reduce available NAD and thus inhibit pyruvate decarboxylation by PDH?
She has a vitamin C deficiency. Scurvy features swollen gums, easy bruising, petechiae, perifollicular and subperiosteal hemorrhages.
submitted by thelupuswolf(9)
Perifollicular hyperkeratosis and hemorrhage are seen with corkscrew hairs, that juicy buzz word for Vit. C deficiency. Hydroxylation of proline in collagen synthesis cannot occur without vitamin c