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md_caffeiner
Quick question: FA19 691 says Leuprolide ClINICAl USE is Uterine fibroids, endometriosis, precocious
puberty, prostate cancer, infertility...
I guess all except infetility(pulsatile?) are used as continuous?
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usmlecrasher
GnRH is synthesized and released in pulsatile fashion , so if you give in pulsatile way you induce GnRH effect , and if given in continuous way it will suppress synthesis, depended the desired effect you want to achieve - infertility induce GnRH with pulsatile , stop synthesis for prostate cancer , testicular cancer , hormone dependent Breast cancer give continuous
+1
djeffs1
I thought Gonadotropin was released by the Hypothalamus, not the pituitary gland. am I crazy?
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kevintkim4
^ Gonadotropins are referring to LH/FSH; Gonadotropin-releasing hormone (GRH) is released by the hypothalamus
+2
dlakaswnd
ffffff.. the way they worded question was so confusing.
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submitted by โhayayah(1212)
GnRH agonists like Leuprolide are effective for patients with breast CA because if given in a continuous fashion, they downregulate the GnRH receptor in the pituitary and ultimately decrease FSH and LH.