GnRH agonists like Leuprolide are effective for patients with breast CA because if given in a continuous fashion, they downregulate the GnRH receptor in the pituitary and ultimately decrease FSH and LH.
md_caffeinerQuick question: FA19 691 says Leuprolide ClINICAl USE is Uterine fibroids, endometriosis, precocious
puberty, prostate cancer, infertility...
I guess all except infetility(pulsatile?) are used as continuous?+1
usmlecrasherGnRH is synthesized and released in pulsatile fashion , so if you give in pulsatile way you induce GnRH effect , and if given in continuous way it will suppress synthesis, depended the desired effect you want to achieve - infertility induce GnRH with pulsatile , stop synthesis for prostate cancer , testicular cancer , hormone dependent Breast cancer give continuous +1
djeffs1I thought Gonadotropin was released by the Hypothalamus, not the pituitary gland. am I crazy?+
kevintkim4^ Gonadotropins are referring to LH/FSH; Gonadotropin-releasing hormone (GRH) is released by the hypothalamus +2
submitted by โhayayah(1212)
GnRH agonists like Leuprolide are effective for patients with breast CA because if given in a continuous fashion, they downregulate the GnRH receptor in the pituitary and ultimately decrease FSH and LH.