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Retired NBME 20 Answers

nbme20/Block 3/Question#8 (reveal difficulty score)
A 12-year-old girl is brought to the ...
Polyubiquitination 🔍 / 📺 / 🌳 / 📖
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submitted by hayayah(1212)
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Atrophy is decrease in tissue mass due to decrease in size (increased cytoskeleton degradation via ubiquitin-proteasome pathway and autophagy;  decreased protein synthesis) and/or number of cells (apoptosis). Causes include disuse, denervation, loss of blood supply, loss of hormonal stimulation, poor nutrition.

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mambaforstep  FA 2019 pg 206 +2



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submitted by weenathon(70)
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Anybody know why fatty acid degradation doesn't play a role?

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andro  The question specifically asks for a process in myocytes Fatty Acids ( Triglycerides ) are primarily stored in adipocytes . It is from adipocytes, that the fat can be mobilized for use by other cells . Loss of adipocytes can decrease the width of the calf , but then again we are talking about mechanisms of muscle atrophy and the most important mechanisms for this is ubiquitination - breakdown of the cytoskeleton proteins +4



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