NBME 20 Epstein-Barr virus genome (NBME Answers)

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Retired NBME 20 Answers

nbme20/Block 3/Question#42 (reveal difficulty score)
A 13-year-old girl has an episode of severe ...
Epstein-Barr virus genome 🔍 / 📺 / 🌳 / 📖
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submitted by ms2991(8)

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FA 2018 page 165--> EBV is "associated with lymphoproliferative disease in transplant patients"

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+4 upvote downvote
submitted by ∗waterloo(126)

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when CMV is involved in post transplant patients that typically causes pneumonia. I think that was a question in this NBME too. For EBV post transplant, it would be lymphadenopathy etc. That's what I've taken away so far from nbme. I thought maybe the monomorphous B lymphocytes was hinting more towards EBV too, but I don't see why CMV wouldn't remain latent in a B lymphocyte?

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uloveboobs CMV definitely could remain latent in a B lymphocyte, but also is latent in T cells and macrophages (i.e., all mononuclear cells). I think the key in this question is the phrase "monomorphous population of B cells." EBV remains latent in B cells ONLY, whereas CMV is latent in all mononuclear (not just B) cells. +14

rockodude ^this is the main point of the question. CMV can cause lymphadenopathy and hepatosplenomegaly as well. Key is the monomorphous phrase. +3

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submitted by nickybeezle(2)

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Human B cells are the primary targets of Epstein Barr virus (EBV) infection. In most cases EBV infection is asymptomatic because of a highly effective host immune response but some individuals develop self-limiting infectious mononucleosis, while others develop EBV-associated lymphoid or epithelial malignancies.

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-3 upvote downvote
submitted by ∗medbitch94(56)

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946499/

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masonkingcobra The pathogenesis of post-transplant lymphoproliferative disorders (PTLD) in most patients relates to the outgrowth of Epstein-Barr virus (EBV)-positive B cell proliferations in the setting of chronic T cell immunosuppression. +3

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