share email twitter ⋅ join discord whatsapp(2ck)
Free 120  NBME 24  NBME 23  NBME 22  NBME 21  NBME 20  NBME 19  NBME 18  NBME 17  NBME 16  NBME 15  NBME 13 
introducing : the “predict me” score predictor NEW!

NBME 20 Answers

nbme20/Block 4/Question#48 (36.5 difficulty score)
A 24-year-old man comes to the emergency ...
Lipoprotein lipase🔍

Login to comment/vote.

Tutor box

Members from the Leaderboard offering 1-on-1 help: Want to be listed here? Email us!

submitted by hayayah(1076),
unscramble the site ⋅ remove ads ⋅ become a member ($39/month)

.tP ahs iimFaall mii.pyeasildds epyT rpoi.meacIHmcrylio—ehyn

estefanyargueta  Lipoprotein lipase: degradation of TGs circulating in chylomicrons and VLDLs. +2  
breis  FA 2019 pg 94 +4  

submitted by blanee1380(2),

Very large increase in TGs causes pancreatitis.
Deficiencies in:

Apo B-100: Type II familial hypercholesterolemia, increases mostly LDL which increases cholesterol

Apo E: Decreased remnant uptake, which increases mostly chylomicrons and VLDL, but it's milder so no pancreatitis.

HSL: deficiency would decrease TGs, not increase

LDL receptor: Type II hypercholesterolemia also

So lipoprotein lipase deficiency is the anser, which causes large increase in chylomicrons and TGs, leading to pancreatitis and has a creamy layer in supernatant.

submitted by pg32(152),

Can anyone explain why the lipase concentration is so high if there is an issue with LPL in hyperchylomicronemia?

garima  due to pancreatitis +5  
neovanilla  ELI5? +  
suckitnbme  @neovanilla Type 1-hyperchylomicronemia has increased risk of pancreatitis +  
makingstrides  I don't understand why this isn't hypertriglyceridemia because this also causes acute pancreatitis. Maybe because overproduction of VLDL isn't an answer? +