NBME 20 Increased osteoclast maturation and activity (NBME Answers)

Retired NBME 20 Answers

nbme20/Block 2/Question#7 (reveal difficulty score)
A 30-year-old man comes to the physician ...
Increased osteoclast maturation and activity 🔍 / 📺 / 🌳 / 📖
tags: endo PTH

+11 upvote downvote
submitted by cafeaulait(11)

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I lbeveei hsit etms yma be nngerfiir EMN 1 rnsydemo - lpoisbes roaamignts cte(pip uelrc eesadis x)d, rihpatroday nmeoaa,d nda iairpuytt oeaadnm g(uscina SH.IA)D But, uoy 'odtn ndee to veen onkw stih ot gte thsi gtirh - sjut ganski the efetcf of ihgh TPH no the essymt - acusse adciresen oalcesotts ittiavyc sa well as uotria.amtn

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fatboyslim Teh pmmtossy of shti inpttea rea ued to pacameierchyl st(nse,o se,obn ,srngao HTSONER neia[rsedc rsdi}e,uis nad aiyprtcihsc re.v)tnoeos Hecipeyaclamr can also eucsa etppci rucle ae.esisd oS teh rmaiypr gaoptoyhl si porhtdrayia iaeadlpmnho/yaeapsr aiuscng hte pereycalicham +6

beetbox sDoe oyenna okwn sw'aht up twih teh 'no bimisratnaole in humurse yr?Xd'iaD eyth sujt hrowt htta in ofr no eso?rna I got dheoko no ti, I ohuthtg etrhe was on dsecaenri asstcoelto vacy.itt.i. horitewes hte ocitcral nbeso ldouw vhae eebn yddol inht or oshtniemg +4

topgunber MNE 1 - P P P . t,aoPrdiyarh stprnsenaraacig( in shit ,s)cea piuitrtay se.oinl ont kye ot snnigeawr hits .qietoutsn p escom thwi tyssmmop fo lmceyiareap,hc snm,ao sonar,g hsoetrn neip(ge,) cyhps oestLo vok.noer at pht and al.ucmci ew see ghhi ac and hhig t.ph eW kwon htta ihhg maiclcu lowdu erolw ..hthpt.is aesmn eht hghi ilcacum saw ued ot hte hghi htp (.i.e roidahayprt o)anmso edniaeutQ si caatlylu :skanig htwa rea teh tfsfeec fo P?TH a, c, pposetoi of TD PH and E i iedevble 'rtnae eredtla to -nTds BSHouP ienghosmt ekil teh hnesoigsptae of -srpFdhiyhiyuoseo petmparad we itfeylndei kwno atth PHT sieeacsnr aC , os by iaregnisnc ooastctlse riycmtuoavntttai/ia yuo eeirbtal cclmuia toin het l.doob iths is teh stbe nesra.w +3

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submitted by ∗laminin(18)

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can mseeoon xniaple wyh it ysas eh hsa na na'tc'ti HTP stnoe.nc.ancioti.r ti to tle us oknw hatt eth HTP rootncecannti si a terlsu fo oanytalgd?p ho w'asht shi x?d ktahn!s

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yotsubato I awser thye emak pu oems fo iths sfuft. kieL hwsat pu hwit hte hsi,trt ,uatnnirio dan ceippt ruecl disa.sese +9

redvelvet iaecarheyplmc can acesu nencgherpoi tsedabei ni;pussdi so rhtit,s aonnturii. aeyeimrpalchc nac aosl auecs tppice lcrue adsesie. sHi otpsmysm are all oubta ypelemhcaairc ued to hiraspotrhdp.mryaeyi +4

namira ceariype"Hamcl can aseuc lnrea utndoisncyf cush sa cneniehrgop sdbaetie snidpisiu N,()DI tbu teh hsciesmmna derngnluiy dhuynmcricalacee-pied DNI ear ton lwle osd.tnreo "duiwny48lwn7/-o):e/ra9-e.(/littir/63rStickef0sxn0apl0/5u01nteo-tg5t8wdh3a2lt. +2

dulxy071 hyW c'tan the cetcror snrewa be C) hicwh potins adtwros lnear arfilu,e wcihh aym dlea to aydncsoer atipydsmrirrhoehayp vghian the eams essltru I ibveeel +2

pmofmalasia The nserycoad prpymdyeharstrahoii in rlnea feriual is due ot ssol of iualccm ni the gnniuoconfn-int di.kney nI ihts itosunqe hte ulmaicc aws de,elvtea so uyo nac erul uto rnela iuer.lfa +1

sars ycae-Haerclipm ucssae etonss (macicul )nessto, gronsa n(ntiopti,co)sa snetorh e(einarcsd nun)iitar,o beson aderic(esn tesltooasc nciot)v,tiaa nad tyhrpscicai eortvnose edsrop)(is.en +1

epiglotitties oout@batsy olsa as eonmsoe noetdmeni in oanehtr mtncm,eo i tkinh 'eteyhr ngihtin that het px htgim avhe 1NE.M roirPthdaay rpa-yihsaelp cepyr,maihcela rayiuttip d-eamnoa IAHDS aitit)un+s,otnh(rir nad acrecipnat m-ortu oasmnrtgai iptce(p celur ssaede)i +

+2 upvote downvote
submitted by killme(14)

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The cetcpon bngei tetsde si t"haw eosd THP do ahtt slade ot pciylaehac"mreibnisa/Kpdg.tb3:Pgs.mje/p/ith/.ocV

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yotsubato g,uh .thlubils I was tyingr ot ieufgr tou na lcuata sedeisa osrpces hee.r +7

rio19111 its mprayir ritrrpdmeipasaoyyhh seuadc yb paoydtirahr m.eaoadn adtidnio of teh ptpcie leucr eusgtsg Zrglnoiel t-;&-g- N1ME tu b nneo of htat is pim absuece ttsha' tno htwa ehyt era asingk. All yeth rea angsik for is teh ciuotnfn fo HT.P +3

topgunber EMN 1 - P P P . hrtyPaodir,a eip(aaarstngnsrc in ihts e)csa, aiurpttyi eno.sli nto key ot nanrwgsie shti tqtes.iopun ecsom iwht syotsmpm of crcypei,haamel snoam, ,aogrns hrnoest gpein,e() hpcsy .rLok onoevtsoe at tph nda ciucl.ma ew see gihh ca nad ihgh .hpt eW kwon hatt hgih uiccaml lowud lweor ..ths.tpih seamn teh high iauclmc wsa ued ot eth hgih thp (..ei tdhypaaoirr esunioQ tnemao)da is atlycalu ksiga:n tahw era eth fctseef of TH?P ,a ,c piopteso fo D TPH dna E i ebvieedl aern't redteal to -TnPHdSsouB ognhimets eikl teh goiesaehsntp of ieoropehhyaads-suFptiyrp md ew etnlfeyidi wkno that PTH csrneeais Ca , so yb gnceraisni otoclasest tiitmaatuactirovy/n yuo eilbatre lcicmua toni hte olo.db tihs is eth bste aes.wnr +1

+2 upvote downvote
submitted by ∗sympathetikey(1600)

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nI oiaidndt to THP = tsoasolcet atvcitiy = ndseaicer ucilc,ma shit eopnsr ulocd soal be gebtnihxii opstsymm fo M.E1N

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topgunber MNE 1 - P P P . aoy,itdPahrr npartgai(rsacesn in isth )cas,e ttyriupai snoeli. otn eky to nirwenags ihst uptqosnit.e cmeso tiwh spmtosym fo ech,lrpyceaaim o,sman sga,orn ehntsor (p),neegi chspy r.oetv kLnoeoso at thp dan lam.ucci ew ees high ac nda hghi pht. eW wkon htat high amciclu dulwo roewl .thp.tsih. ensam eth ihgh uacmcil saw deu to hte ihgh tph .(i.e idraoaypthr dtmena)Qu enoasio si ultyclaa in:agsk awht aer the etescff of PH?T a, c, eotpsipo fo P DHT nda E i eblveeid taer'n deaetlr ot BuoHP TdnsS- egmtnoihs ielk het osseaitehgpn fo ayphti oeaymp-dsouFidpsrhre ew ledytinife wnko ttha PTH ncreseais aC , so yb ernscigina aosclotets otaraimcntyut/iiatv yuo iaebrtle mciulac noit hte d.obol htsi si eht tsbe wsn.era +1

+1 upvote downvote
submitted by rio19111(16)

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tis pryrmai ayrpmhrorsdiiphtaey aduesc yb rdoapartyhi .amadnoe ddtioain of het icppet ulcre susetgg lrngoZlie -;t-&-g 1MEN

tub noen fo taht si pim seuecab atsth' ont htwa etyh rae .gkansi llA yeth era naskig orf is eht tnifucno of PHT.

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rio19111 e,nsoSt sno,gar erntoh,s thiparccsyi vnesotreo &t-;--g ympomsts +1

topgunber NME 1 - P P P . ayitParrdo,h rs(crnsiatagnape in itsh ca,se) rypiuatit .lenosi not key to inaewsgnr shti te.inpoq stu mecos thwi mosyspmt fo acel,pecramiyh ,nmsao ar,nsgo toherns ,eeg)nip( syhpc e.oo rLevntosko ta pth nda ial.ucmc we see gihh ac and high pht. eW wkon taht hhig lcaumci dwolu lwoer .t..iphhts nsmea teh hhig mlcucai aws ude to teh hihg tph ..(ei ptryoharida )oneianetdamosuQ si lauctyla gsni:ka hatw are eht fsecetf fo ?HPT a, ,c tioppose fo P HTD adn E i eidvlbee nare't taerdle to dS-BsoHunPT tegniosmh ilke teh eghiseapston of deheps-y ruosrphaimyptFaoid we eteflyidni onwk htta HPT saeneicrs aC , so by ngriaisnec etlsscoota c/viyomrutantattiai ouy eeirblat aumcilc toni hte dobol. iths si the tebs r.waesn +1

+0 upvote downvote
submitted by ∗nwinkelmann(366)

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esDo ynoean wkon hte ccinaisiengf fo mocyotne ?imtotliy

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submitted by arthur_albuquerque(1)

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aWth eepdhl me to aswrne hsti eon ueitq lsiyae was het olfwinglo naa:roitle

yipaeemalccHr + ighh HTP -g;&t iry"apmr psrhihyraademto"pyri

How do gihh HTP adel to eapariecych?ml nsnciaIrge osaleotsct !itaviyct

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+0 upvote downvote
submitted by ∗topgunber(68)

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EMN 1 - P P P . datiryhP,roa rsciea(ntpraagsn in isht sc)a,e itutpryai ine.osl ton kye ot agnwisrne isth toeqs.uni

tp comes wtih somytsmp of e,ralpymccahei s,mano a,onsgr seorhtn ,pieneg() scyph roteove.sn

ookL ta thp nad .maccliu we see ihgh ca nad hgih th.p eW wnok atht ghih aimcclu loudw woler ip..thsth. emnas eht ighh clmciua saw ued ot the ihhg thp .i.e( aidyhtoarpr eonamda)

tQinoesu si ytacuall nagiks: awht rae het efeftcs fo HT?P a, c, ppotiseo of THP

D nad E i eedleibv arn'te dlatere to TPH

SB-unods hesingtmo eikl eht gsistpanohee fo hoopyeehysppamdduirarits

-F ew itenydlfei nowk taht PHT rneecaiss aC , so by naersniigc ctaoetsosl narviotatctm/yuitia uyo latereib laccium toni eth do.obl isht is teh tesb .srneaw

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