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NBME 20 Answers

nbme20/Block 3/Question#31 (19.3 difficulty score)
A 62-year-old woman comes to the physician ...

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submitted by dickass(78),

Paclitaxel hyperstabilizes polymerized microtubules (made up of alpha- and beta- tubulin)

md_caffeiner  And clinical use is in breast and ovarian CA (FA19 433) +2  
len49  TAXes stabilize society. +  
alimd  Tarzan: taxanes (e.g. paclitaxel, docetaxel, cabazitaxel. SKETCHY +  

submitted by celeste(68),
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uulBtabin-eT si a nsubuti of iltbnuu. uTublin si oen fo eseralv rmebsme fo a asmll mafyli of abgorull ip.soertn tI si eth ojmra etisotuntnc of utlum.iocersb Trhee era wto fo ostm ocommn mbmsere of teh blutuni iafm:yl ualub-itahlnp nda tuut-nlaebb,i nad rgeoteht hitre sriedm omfr ciour.semtubl (m.ceoogeirn)

submitted by xxabi(228),
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Vcain adn tpaln aioklsald dbni uln,-uBtib iwhch nbiishti het fonrmaoti or syideslmbas ro cbsuemtu,lior evpytrc.eelis

md_caffeiner  Vinca is a plant alkaloid and it has vinblastin, vincristine, which bind β-tubulin and inhibit its polymerization into microtubules Paclitaxel hyperstabilizes and prevents breakdown, its not a Vinca alkaloid. (FA+Wikipedia) +1  
md_caffeiner  What I mean is they are both derived from plants. +