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NBME 20 Answers

nbme20/Block 2/Question#22 (31.6 difficulty score)
A 44-year-old woman comes to the physician ...
Ubiquitin ligase🔍

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submitted by hayayah(1057),
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In rutkoceiya lsl,ce tow roajm hahstytape—w pbomie-eiqusnratiuot aawypth dan ylslmooas isem—aelepritdosyto pnieotr .odareagndti

hTe jroma ahtwayp fo vteeiscel epitnro anodeaidtrg ni rociatkyeu clles ssue iuibiqtun sa a arkrme tath tsgerat tocilsyco and cnaerul osripent rfo ipard se.roytoplsi

hTe trheo roajm tyhaawp of porenit egoddanatir in roiayketcu celsl noilvsev the kuaept of esntprio by smoloseys and idnogstei by o.rseepast

missi199  Could I ask why it is not Lysosomal protease +7  
smc213  "Certain viruses have evolved to recruit the cellular E3 ligases to induce the degradation of cellular proteins that might have harmful effects on the viral life cycle. For instance, the protein E6 of Human papillomavirus (HPV) recruits the cellular E3 ubiquitin ligase E6-AP to induce ubiquitination and degradation of p53, thereby allowing viral replication." from: +3  
smc213  USMLE Kaplan: A majority of cellular proteins are degraded via the ubiquitin proteasome pathway, including many proteins that play a role in maintaining cellular homeostasis. These include proteins that regulate the cell cycle, apoptosis, etc. +3