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Retired NBME 20 Answers

nbme20/Block 2/Question#37 (reveal difficulty score)
A 28-year-old woman of Eastern European ...
Recombinational double-stranded DNA break repair ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +8  upvote downvote
submitted by โˆ—hayayah(1212)
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Defective homologous recombination is seen in breast/ovarian cancers with the BRCA1 gene mutation.

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johnthurtjr  Ashkenazi Jews have a higher risk of inheriting the BRCA1 and BRCA 2 gene mutations, just another tip! +3
lebron james  BRCA1/BRACA2 are involved in the repair of DNA double stranded breaks +8
samsam3711  Other answers: DNA Mismatch Repair: Lynch Syndrome (MLH1, MSH2) DNA Nucleotide Excision Repair: Xeroderma Pigmentosa +17
lovebug  not about this question but... Defective "Non"-homologous end joining is seen in Ataxia-telangiectasia. :) +4
makingstrides  DNA Base excision repair removed damaged, or not correct, bases. +



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