Heparin-induced thrombocytopenia (HIT) is the development of IgG antibodies against heparin bound platelet factor 4 (PF4). Antibody-heparin-PF4 complex activates platelets ย thrombosis and thrombocytopenia. Highest risk with unfractionated heparin.
drwcould you also help to understand:
1) could anti-heparin-PF4 complex be also called anti-PLT antibody?
2) PLT reduction is due to both PLT thrombosis consumption and elimination in the spleen, then why hypersplenism is not correct?+
charcot_bouchardhypersplenism means bigger spleen eating everything. thats not the case here. here spleen is normal. autoimmune cause+
benitezmenaYes I dont understand why the called them Anti-platyelet antibodies and not specifically Anti-heparin bound to PF4 on platelets. Its just not the right antibody+3
benitezmenaAntiplatelet antibodies would be for ITP, but also anti-megakaryocyte antibodies would also be for ITP.+2
misterdoctor69As an aside, pregnancy is a hypercoagulable state which caused her DVT in the first place+1
cport12If anyone else was freaking out about the word hemodilution basically it just means that there is a decreased concentration of cells and solids in the blood resulting from some other gain of fluid. With normal pregnancy (not HIT), blood volume increases, which results in a hemodilution.+3
kcyanide101This question is kinda confusing... based off what i got from UWORLD there are 2 types of HIT
type 1: thrombosis n thrombocytopenia. 5 days after . Usually due to sp[lenic damage
type 2 You get thrombocytopenia but no thrombosis. Onset in 2 days and it is usually due to non immune process+
submitted by โhayayah(1212)
Heparin-induced thrombocytopenia (HIT) is the development of IgG antibodies against heparin bound platelet factor 4 (PF4). Antibody-heparin-PF4 complex activates platelets ย thrombosis and thrombocytopenia. Highest risk with unfractionated heparin.