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NBME 20 Answers

nbme20/Block 3/Question#2 (reveal difficulty score)
A 23-year-old woman is brought to the ...
Xanthine oxidase ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: pharm

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 +21  upvote downvote
submitted by โˆ—karljeon(140)

This one was a somewhat simple question since chemotherapy --> tumor lysis --> need xanthine oxidase inhibitor (eg, febuxostat).


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malou  I swear I registered just to upvote your comment. #SoFrustratedToo +1
xoxofossagirl  ,omg, me, too, , +1

 +2  upvote downvote
submitted by โˆ—hayayah(1212)

Allopurinol inhibits xanthine oxidase. It is used for chronic gout as well as prevention of tumor-lysis associated urate nephropathy.

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betcher  I got confused because the question stem she was on an extensive chemotherapy regimen and got scared away from Xanthine Oxidase because of its potentially for interaction with 6MP/Azathioprene, but I guess since neither of those were directly stated in the question stem I should have gone with Xanthine Oxidase inhibitor to prevent tumor lysis as stated above +1

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submitted by โˆ—breis(56)

Dx: Acute Monocytic Leukemia. Proliferation of monoblasts; lack MPO. CD14 + CD13+ MPO -. blasts characteristically infiltrate the gums.

A Xanthine Oxidase inhibitor is given to prevent adverse reactions of Tumor Lysis Syndrome which results from expulsion of cellular debris/material after the cell dies.

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srmtn  FA 2019 p 426 +

She has Leukemia- to prevent tumor lysis syndrome give her Allopurinol which is xanthine oxidase inhibitor page 435 FA 2020

+5/- compasses(14)

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